Systematic Functional Analysis of PINK1 and PRKN Coding Variants

Loss of either PINK1 or PRKN causes an early onset Parkinson’s disease (PD) phenotype. Functionally, PINK1 and PRKN work together to mediate stress-activated mitochondrial quality control. Upon mitochondrial damage, PINK1, a ubiquitin kinase and PRKN, a ubiquitin ligase, decorate damaged organelles...

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Detalles Bibliográficos
Autores principales: Broadway, Benjamin J., Boneski, Paige K., Bredenberg, Jenny M., Kolicheski, Ana, Hou, Xu, Soto-Beasley, Alexandra I., Ross, Owen A., Springer, Wolfdieter, Fiesel, Fabienne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367835/
https://www.ncbi.nlm.nih.gov/pubmed/35954270
http://dx.doi.org/10.3390/cells11152426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367835/
https://www.ncbi.nlm.nih.gov/pubmed/35954270
http://dx.doi.org/10.3390/cells11152426

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