Cargando…
Nutraceuticals and Food-Grade Lipid Nanoparticles: From Natural Sources to a Circular Bioeconomy Approach
Nutraceuticals have gained increasing attention over the last years due to their potential value as therapeutic compounds formulated from natural sources. For instance, there is a wide range of literature about the cardioprotective properties of omega-3 lipids and the antioxidant value of some pheno...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367884/ https://www.ncbi.nlm.nih.gov/pubmed/35954085 http://dx.doi.org/10.3390/foods11152318 |
_version_ | 1784765948049227776 |
---|---|
author | Blanco-Llamero, Cristina Fonseca, Joel Durazzo, Alessandra Lucarini, Massimo Santini, Antonello Señoráns, Francisco J. Souto, Eliana B. |
author_facet | Blanco-Llamero, Cristina Fonseca, Joel Durazzo, Alessandra Lucarini, Massimo Santini, Antonello Señoráns, Francisco J. Souto, Eliana B. |
author_sort | Blanco-Llamero, Cristina |
collection | PubMed |
description | Nutraceuticals have gained increasing attention over the last years due to their potential value as therapeutic compounds formulated from natural sources. For instance, there is a wide range of literature about the cardioprotective properties of omega-3 lipids and the antioxidant value of some phenolic compounds, which are related to antitumoral activity. However, the value of nutraceuticals can be limited by their instability under gastric pH and intestinal fluids, their low solubility and absorption. That is why encapsulation is a crucial step in nutraceutical design. In fact, pharmaceutical nanotechnology improves nutraceutical stability and bioavailability through the design and production of efficient nanoparticles (NPs). Lipid nanoparticles protect the bioactive compounds from light and external damage, including the gastric and intestinal conditions, providing a retarded delivery in the target area and guaranteeing the expected therapeutic effect of the nutraceutical. This review will focus on the key aspects of the encapsulation of bioactive compounds into lipid nanoparticles, exploring the pharmaceutical production methods available for the synthesis of NPs containing nutraceuticals. Moreover, the most common nutraceuticals will be discussed, considering the bioactive compounds, their natural source and the described biological properties. |
format | Online Article Text |
id | pubmed-9367884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93678842022-08-12 Nutraceuticals and Food-Grade Lipid Nanoparticles: From Natural Sources to a Circular Bioeconomy Approach Blanco-Llamero, Cristina Fonseca, Joel Durazzo, Alessandra Lucarini, Massimo Santini, Antonello Señoráns, Francisco J. Souto, Eliana B. Foods Review Nutraceuticals have gained increasing attention over the last years due to their potential value as therapeutic compounds formulated from natural sources. For instance, there is a wide range of literature about the cardioprotective properties of omega-3 lipids and the antioxidant value of some phenolic compounds, which are related to antitumoral activity. However, the value of nutraceuticals can be limited by their instability under gastric pH and intestinal fluids, their low solubility and absorption. That is why encapsulation is a crucial step in nutraceutical design. In fact, pharmaceutical nanotechnology improves nutraceutical stability and bioavailability through the design and production of efficient nanoparticles (NPs). Lipid nanoparticles protect the bioactive compounds from light and external damage, including the gastric and intestinal conditions, providing a retarded delivery in the target area and guaranteeing the expected therapeutic effect of the nutraceutical. This review will focus on the key aspects of the encapsulation of bioactive compounds into lipid nanoparticles, exploring the pharmaceutical production methods available for the synthesis of NPs containing nutraceuticals. Moreover, the most common nutraceuticals will be discussed, considering the bioactive compounds, their natural source and the described biological properties. MDPI 2022-08-03 /pmc/articles/PMC9367884/ /pubmed/35954085 http://dx.doi.org/10.3390/foods11152318 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Blanco-Llamero, Cristina Fonseca, Joel Durazzo, Alessandra Lucarini, Massimo Santini, Antonello Señoráns, Francisco J. Souto, Eliana B. Nutraceuticals and Food-Grade Lipid Nanoparticles: From Natural Sources to a Circular Bioeconomy Approach |
title | Nutraceuticals and Food-Grade Lipid Nanoparticles: From Natural Sources to a Circular Bioeconomy Approach |
title_full | Nutraceuticals and Food-Grade Lipid Nanoparticles: From Natural Sources to a Circular Bioeconomy Approach |
title_fullStr | Nutraceuticals and Food-Grade Lipid Nanoparticles: From Natural Sources to a Circular Bioeconomy Approach |
title_full_unstemmed | Nutraceuticals and Food-Grade Lipid Nanoparticles: From Natural Sources to a Circular Bioeconomy Approach |
title_short | Nutraceuticals and Food-Grade Lipid Nanoparticles: From Natural Sources to a Circular Bioeconomy Approach |
title_sort | nutraceuticals and food-grade lipid nanoparticles: from natural sources to a circular bioeconomy approach |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367884/ https://www.ncbi.nlm.nih.gov/pubmed/35954085 http://dx.doi.org/10.3390/foods11152318 |
work_keys_str_mv | AT blancollamerocristina nutraceuticalsandfoodgradelipidnanoparticlesfromnaturalsourcestoacircularbioeconomyapproach AT fonsecajoel nutraceuticalsandfoodgradelipidnanoparticlesfromnaturalsourcestoacircularbioeconomyapproach AT durazzoalessandra nutraceuticalsandfoodgradelipidnanoparticlesfromnaturalsourcestoacircularbioeconomyapproach AT lucarinimassimo nutraceuticalsandfoodgradelipidnanoparticlesfromnaturalsourcestoacircularbioeconomyapproach AT santiniantonello nutraceuticalsandfoodgradelipidnanoparticlesfromnaturalsourcestoacircularbioeconomyapproach AT senoransfranciscoj nutraceuticalsandfoodgradelipidnanoparticlesfromnaturalsourcestoacircularbioeconomyapproach AT soutoelianab nutraceuticalsandfoodgradelipidnanoparticlesfromnaturalsourcestoacircularbioeconomyapproach |