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Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43

TAR DNA-binding protein 43 (TDP-43) is a predominant component of inclusions in the brains and spines of patients with amyotrophic lateral sclerosis (ALS). The progressive accumulation of inclusions leads to proteinopathy in neurons. We have previously shown that Met1(M1)-linked linear ubiquitin, wh...

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Detalles Bibliográficos
Autores principales:	Zhang, Qiang, Terawaki, Seigo, Oikawa, Daisuke, Okina, Yoshinori, Usuki, Yoshinosuke, Ito, Hidefumi, Tokunaga, Fuminori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367985/ https://www.ncbi.nlm.nih.gov/pubmed/35954242 http://dx.doi.org/10.3390/cells11152398

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