Faster Serotonin Clearance in CA3 Region of Hippocampus and Antidepressant-like Effect of Decynium-22 in Juvenile Mice Are Putatively Linked to Increased Plasma Membrane Monoamine Transporter Function: Implications for Efficacy of Antidepressants in Juveniles

Selective serotonin reuptake inhibitors (SSRIs) are less efficacious in treating depression in children than in adults. SSRIs block serotonin uptake via the high-affinity, low-capacity serotonin transporter. However, the low-affinity, high-capacity organic cation transporter 3 (OCT3) and plasma memb...

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Detalles Bibliográficos
Autores principales: Bowman, Melodi A., Gomez, Jorge A., Mitchell, Nathan C., Wells, Anne M., Vitela, Melissa, Clarke, Kyra M., Horton, Rebecca E., Koek, Wouter, Daws, Lynette C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368098/
https://www.ncbi.nlm.nih.gov/pubmed/35954298
http://dx.doi.org/10.3390/cells11152454

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