Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease

Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modification. Two major histone mono-ubiquitination events are the m...

Descripción completa

Detalles Bibliográficos
Autores principales: Oss-Ronen, Liat, Sarusi, Tzlil, Cohen, Idan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368181/
https://www.ncbi.nlm.nih.gov/pubmed/35954248
http://dx.doi.org/10.3390/cells11152404
_version_ 1784766042192478208
author Oss-Ronen, Liat
Sarusi, Tzlil
Cohen, Idan
author_facet Oss-Ronen, Liat
Sarusi, Tzlil
Cohen, Idan
author_sort Oss-Ronen, Liat
collection PubMed
description Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modification. Two major histone mono-ubiquitination events are the mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub), placed by Polycomb repressive complex 1 (PRC1), and histone H2B lysine 120 mono-ubiquitination (H2BK120ub), placed by the heteromeric RNF20/RNF40 complex. Both of these events play fundamental roles in shaping the chromatin epigenetic landscape and cellular identity. In this review we summarize the current understandings of molecular concepts behind histone mono-ubiquitination, focusing on their recently identified roles in tissue development and pathologies.
format Online
Article
Text
id pubmed-9368181
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93681812022-08-12 Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease Oss-Ronen, Liat Sarusi, Tzlil Cohen, Idan Cells Review Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modification. Two major histone mono-ubiquitination events are the mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub), placed by Polycomb repressive complex 1 (PRC1), and histone H2B lysine 120 mono-ubiquitination (H2BK120ub), placed by the heteromeric RNF20/RNF40 complex. Both of these events play fundamental roles in shaping the chromatin epigenetic landscape and cellular identity. In this review we summarize the current understandings of molecular concepts behind histone mono-ubiquitination, focusing on their recently identified roles in tissue development and pathologies. MDPI 2022-08-04 /pmc/articles/PMC9368181/ /pubmed/35954248 http://dx.doi.org/10.3390/cells11152404 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oss-Ronen, Liat
Sarusi, Tzlil
Cohen, Idan
Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease
title Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease
title_full Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease
title_fullStr Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease
title_full_unstemmed Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease
title_short Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease
title_sort histone mono-ubiquitination in transcriptional regulation and its mark on life: emerging roles in tissue development and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368181/
https://www.ncbi.nlm.nih.gov/pubmed/35954248
http://dx.doi.org/10.3390/cells11152404
work_keys_str_mv AT ossronenliat histonemonoubiquitinationintranscriptionalregulationanditsmarkonlifeemergingrolesintissuedevelopmentanddisease
AT sarusitzlil histonemonoubiquitinationintranscriptionalregulationanditsmarkonlifeemergingrolesintissuedevelopmentanddisease
AT cohenidan histonemonoubiquitinationintranscriptionalregulationanditsmarkonlifeemergingrolesintissuedevelopmentanddisease

Ejemplares similares