MDA5 signaling induces type 1 IFN- and IL-1-dependent lung vascular permeability which protects mice from opportunistic fungal infection

Lungs balance threat from primary viral infection, secondary infection, and inflammatory damage. Severe pulmonary inflammation induces vascular permeability, edema, and organ dysfunction. We previously demonstrated that poly(I:C) (pICLC) induced type 1 interferon (t1IFN) protected mice from Cryptoco...

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Detalles Bibliográficos
Autores principales: Davis, Michael J., Martin, Rachel E., Pinheiro, Giovana M., Hoke, Elizabeth S., Moyer, Shannon, Mayer-Barber, Katrin D., Chang, Yun C., Kwon-Chung, Kyung J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368195/
https://www.ncbi.nlm.nih.gov/pubmed/35967332
http://dx.doi.org/10.3389/fimmu.2022.931194

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