The reservoir of latent HIV

The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV is unable to be recognized by the body’s immune system. Currently, the widely adopted antiretroviral therapy (ART)...

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Autores principales: Chen, Jing, Zhou, Tong, Zhang, Yuan, Luo, Shumin, Chen, Huan, Chen, Dexi, Li, Chuanyun, Li, Weihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368196/
https://www.ncbi.nlm.nih.gov/pubmed/35967854
http://dx.doi.org/10.3389/fcimb.2022.945956
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author Chen, Jing
Zhou, Tong
Zhang, Yuan
Luo, Shumin
Chen, Huan
Chen, Dexi
Li, Chuanyun
Li, Weihua
author_facet Chen, Jing
Zhou, Tong
Zhang, Yuan
Luo, Shumin
Chen, Huan
Chen, Dexi
Li, Chuanyun
Li, Weihua
author_sort Chen, Jing
collection PubMed
description The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV is unable to be recognized by the body’s immune system. Currently, the widely adopted antiretroviral therapy (ART) is also unble to eliminate it, thus hindering the progress of HIV treatment. This review discusses the existence of latent HIV vault for HIV treatment, its formation and factors affecting its formation, cell, and tissue localization, methods for detection and removing latent reservoir, to provide a comprehensive understanding of latent HIV vault, in order to assist in the future research and play a potential role in achieving HIV treatment.
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spelling pubmed-93681962022-08-12 The reservoir of latent HIV Chen, Jing Zhou, Tong Zhang, Yuan Luo, Shumin Chen, Huan Chen, Dexi Li, Chuanyun Li, Weihua Front Cell Infect Microbiol Cellular and Infection Microbiology The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV is unable to be recognized by the body’s immune system. Currently, the widely adopted antiretroviral therapy (ART) is also unble to eliminate it, thus hindering the progress of HIV treatment. This review discusses the existence of latent HIV vault for HIV treatment, its formation and factors affecting its formation, cell, and tissue localization, methods for detection and removing latent reservoir, to provide a comprehensive understanding of latent HIV vault, in order to assist in the future research and play a potential role in achieving HIV treatment. Frontiers Media S.A. 2022-07-28 /pmc/articles/PMC9368196/ /pubmed/35967854 http://dx.doi.org/10.3389/fcimb.2022.945956 Text en Copyright © 2022 Chen, Zhou, Zhang, Luo, Chen, Chen, Li and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Chen, Jing
Zhou, Tong
Zhang, Yuan
Luo, Shumin
Chen, Huan
Chen, Dexi
Li, Chuanyun
Li, Weihua
The reservoir of latent HIV
title The reservoir of latent HIV
title_full The reservoir of latent HIV
title_fullStr The reservoir of latent HIV
title_full_unstemmed The reservoir of latent HIV
title_short The reservoir of latent HIV
title_sort reservoir of latent hiv
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368196/
https://www.ncbi.nlm.nih.gov/pubmed/35967854
http://dx.doi.org/10.3389/fcimb.2022.945956
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