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lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions

Hair follicles (HFs) are complex organs that grow cyclically during mammals’ growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, candidate lncRNAs associated with HF cyclic regeneration...

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Autores principales: Zhao, Bohao, Li, Jiali, Liu, Ming, Hu, Shuaishuai, Yang, Naisu, Liang, Shuang, Zhang, Xiyu, Dai, Yingying, Bao, Zhiyuan, Chen, Yang, Wu, Xinsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368379/
https://www.ncbi.nlm.nih.gov/pubmed/35954286
http://dx.doi.org/10.3390/cells11152443
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author Zhao, Bohao
Li, Jiali
Liu, Ming
Hu, Shuaishuai
Yang, Naisu
Liang, Shuang
Zhang, Xiyu
Dai, Yingying
Bao, Zhiyuan
Chen, Yang
Wu, Xinsheng
author_facet Zhao, Bohao
Li, Jiali
Liu, Ming
Hu, Shuaishuai
Yang, Naisu
Liang, Shuang
Zhang, Xiyu
Dai, Yingying
Bao, Zhiyuan
Chen, Yang
Wu, Xinsheng
author_sort Zhao, Bohao
collection PubMed
description Hair follicles (HFs) are complex organs that grow cyclically during mammals’ growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, candidate lncRNAs associated with HF cyclic regeneration were screened, and we identified that the novel lncRNA, lncRNA2919, was significantly expressed during catagen. Here, we identified that lncRNA2919 has no coding potentiality and is highly expressed in the cell nucleus, and downregulates HF growth and development-related genes, inhibits cell proliferation, and promotes cell apoptosis in rabbit dermal papilla cells. lncRNA2919 recruits STAT1 to form a compound. As a key transcription factor, STAT1 regulates the transcriptional expression of KRTAP11-1. Our study revealed that lncRNA2919 is involved in HF cyclic regeneration through the trans-regulatory lncRNA2919–STAT1–KRTAP11-1 axis. This study elucidates the mechanism through which lncRNA2919 regulates HF growth and development and the role of lncRNA2919 as a new therapeutic target in animal wool production and human hair-related disease treatment.
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spelling pubmed-93683792022-08-12 lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions Zhao, Bohao Li, Jiali Liu, Ming Hu, Shuaishuai Yang, Naisu Liang, Shuang Zhang, Xiyu Dai, Yingying Bao, Zhiyuan Chen, Yang Wu, Xinsheng Cells Article Hair follicles (HFs) are complex organs that grow cyclically during mammals’ growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, candidate lncRNAs associated with HF cyclic regeneration were screened, and we identified that the novel lncRNA, lncRNA2919, was significantly expressed during catagen. Here, we identified that lncRNA2919 has no coding potentiality and is highly expressed in the cell nucleus, and downregulates HF growth and development-related genes, inhibits cell proliferation, and promotes cell apoptosis in rabbit dermal papilla cells. lncRNA2919 recruits STAT1 to form a compound. As a key transcription factor, STAT1 regulates the transcriptional expression of KRTAP11-1. Our study revealed that lncRNA2919 is involved in HF cyclic regeneration through the trans-regulatory lncRNA2919–STAT1–KRTAP11-1 axis. This study elucidates the mechanism through which lncRNA2919 regulates HF growth and development and the role of lncRNA2919 as a new therapeutic target in animal wool production and human hair-related disease treatment. MDPI 2022-08-06 /pmc/articles/PMC9368379/ /pubmed/35954286 http://dx.doi.org/10.3390/cells11152443 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhao, Bohao
Li, Jiali
Liu, Ming
Hu, Shuaishuai
Yang, Naisu
Liang, Shuang
Zhang, Xiyu
Dai, Yingying
Bao, Zhiyuan
Chen, Yang
Wu, Xinsheng
lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions
title lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions
title_full lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions
title_fullStr lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions
title_full_unstemmed lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions
title_short lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions
title_sort lncrna2919 suppresses rabbit dermal papilla cell proliferation via trans-regulatory actions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368379/
https://www.ncbi.nlm.nih.gov/pubmed/35954286
http://dx.doi.org/10.3390/cells11152443
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