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lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions
Hair follicles (HFs) are complex organs that grow cyclically during mammals’ growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, candidate lncRNAs associated with HF cyclic regeneration...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368379/ https://www.ncbi.nlm.nih.gov/pubmed/35954286 http://dx.doi.org/10.3390/cells11152443 |
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author | Zhao, Bohao Li, Jiali Liu, Ming Hu, Shuaishuai Yang, Naisu Liang, Shuang Zhang, Xiyu Dai, Yingying Bao, Zhiyuan Chen, Yang Wu, Xinsheng |
author_facet | Zhao, Bohao Li, Jiali Liu, Ming Hu, Shuaishuai Yang, Naisu Liang, Shuang Zhang, Xiyu Dai, Yingying Bao, Zhiyuan Chen, Yang Wu, Xinsheng |
author_sort | Zhao, Bohao |
collection | PubMed |
description | Hair follicles (HFs) are complex organs that grow cyclically during mammals’ growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, candidate lncRNAs associated with HF cyclic regeneration were screened, and we identified that the novel lncRNA, lncRNA2919, was significantly expressed during catagen. Here, we identified that lncRNA2919 has no coding potentiality and is highly expressed in the cell nucleus, and downregulates HF growth and development-related genes, inhibits cell proliferation, and promotes cell apoptosis in rabbit dermal papilla cells. lncRNA2919 recruits STAT1 to form a compound. As a key transcription factor, STAT1 regulates the transcriptional expression of KRTAP11-1. Our study revealed that lncRNA2919 is involved in HF cyclic regeneration through the trans-regulatory lncRNA2919–STAT1–KRTAP11-1 axis. This study elucidates the mechanism through which lncRNA2919 regulates HF growth and development and the role of lncRNA2919 as a new therapeutic target in animal wool production and human hair-related disease treatment. |
format | Online Article Text |
id | pubmed-9368379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93683792022-08-12 lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions Zhao, Bohao Li, Jiali Liu, Ming Hu, Shuaishuai Yang, Naisu Liang, Shuang Zhang, Xiyu Dai, Yingying Bao, Zhiyuan Chen, Yang Wu, Xinsheng Cells Article Hair follicles (HFs) are complex organs that grow cyclically during mammals’ growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, candidate lncRNAs associated with HF cyclic regeneration were screened, and we identified that the novel lncRNA, lncRNA2919, was significantly expressed during catagen. Here, we identified that lncRNA2919 has no coding potentiality and is highly expressed in the cell nucleus, and downregulates HF growth and development-related genes, inhibits cell proliferation, and promotes cell apoptosis in rabbit dermal papilla cells. lncRNA2919 recruits STAT1 to form a compound. As a key transcription factor, STAT1 regulates the transcriptional expression of KRTAP11-1. Our study revealed that lncRNA2919 is involved in HF cyclic regeneration through the trans-regulatory lncRNA2919–STAT1–KRTAP11-1 axis. This study elucidates the mechanism through which lncRNA2919 regulates HF growth and development and the role of lncRNA2919 as a new therapeutic target in animal wool production and human hair-related disease treatment. MDPI 2022-08-06 /pmc/articles/PMC9368379/ /pubmed/35954286 http://dx.doi.org/10.3390/cells11152443 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhao, Bohao Li, Jiali Liu, Ming Hu, Shuaishuai Yang, Naisu Liang, Shuang Zhang, Xiyu Dai, Yingying Bao, Zhiyuan Chen, Yang Wu, Xinsheng lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions |
title | lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions |
title_full | lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions |
title_fullStr | lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions |
title_full_unstemmed | lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions |
title_short | lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions |
title_sort | lncrna2919 suppresses rabbit dermal papilla cell proliferation via trans-regulatory actions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368379/ https://www.ncbi.nlm.nih.gov/pubmed/35954286 http://dx.doi.org/10.3390/cells11152443 |
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