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Microbeam Irradiation as a Simultaneously Integrated Boost in a Conventional Whole-Brain Radiotherapy Protocol

Microbeam radiotherapy (MRT), an experimental high-dose rate concept with spatial fractionation at the micrometre range, has shown a high therapeutic potential as well as good preservation of normal tissue function in pre-clinical studies. We investigated the suitability of MRT as a simultaneously i...

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Autores principales: Jaekel, Felix, Bräuer-Krisch, Elke, Bartzsch, Stefan, Laissue, Jean, Blattmann, Hans, Scholz, Marten, Soloviova, Julia, Hildebrandt, Guido, Schültke, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368396/
https://www.ncbi.nlm.nih.gov/pubmed/35955454
http://dx.doi.org/10.3390/ijms23158319
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author Jaekel, Felix
Bräuer-Krisch, Elke
Bartzsch, Stefan
Laissue, Jean
Blattmann, Hans
Scholz, Marten
Soloviova, Julia
Hildebrandt, Guido
Schültke, Elisabeth
author_facet Jaekel, Felix
Bräuer-Krisch, Elke
Bartzsch, Stefan
Laissue, Jean
Blattmann, Hans
Scholz, Marten
Soloviova, Julia
Hildebrandt, Guido
Schültke, Elisabeth
author_sort Jaekel, Felix
collection PubMed
description Microbeam radiotherapy (MRT), an experimental high-dose rate concept with spatial fractionation at the micrometre range, has shown a high therapeutic potential as well as good preservation of normal tissue function in pre-clinical studies. We investigated the suitability of MRT as a simultaneously integrated boost (SIB) in conventional whole-brain irradiation (WBRT). A 174 Gy MRT SIB was administered with an array of quasi-parallel, 50 µm wide microbeams spaced at a centre-to-centre distance of 400 µm either on the first or last day of a 5 × 4 Gy radiotherapy schedule in healthy adult C57 BL/6J mice and in F98 glioma cell cultures. The animals were observed for signs of intracranial pressure and focal neurologic signs. Colony counts were conducted in F98 glioma cell cultures. No signs of acute adverse effects were observed in any of the irradiated animals within 3 days after the last irradiation fraction. The tumoricidal effect on F98 cell in vitro was higher when the MRT boost was delivered on the first day of the irradiation course, as opposed to the last day. Therefore, the MRT SIB should be integrated into a clinical radiotherapy schedule as early as possible.
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spelling pubmed-93683962022-08-12 Microbeam Irradiation as a Simultaneously Integrated Boost in a Conventional Whole-Brain Radiotherapy Protocol Jaekel, Felix Bräuer-Krisch, Elke Bartzsch, Stefan Laissue, Jean Blattmann, Hans Scholz, Marten Soloviova, Julia Hildebrandt, Guido Schültke, Elisabeth Int J Mol Sci Article Microbeam radiotherapy (MRT), an experimental high-dose rate concept with spatial fractionation at the micrometre range, has shown a high therapeutic potential as well as good preservation of normal tissue function in pre-clinical studies. We investigated the suitability of MRT as a simultaneously integrated boost (SIB) in conventional whole-brain irradiation (WBRT). A 174 Gy MRT SIB was administered with an array of quasi-parallel, 50 µm wide microbeams spaced at a centre-to-centre distance of 400 µm either on the first or last day of a 5 × 4 Gy radiotherapy schedule in healthy adult C57 BL/6J mice and in F98 glioma cell cultures. The animals were observed for signs of intracranial pressure and focal neurologic signs. Colony counts were conducted in F98 glioma cell cultures. No signs of acute adverse effects were observed in any of the irradiated animals within 3 days after the last irradiation fraction. The tumoricidal effect on F98 cell in vitro was higher when the MRT boost was delivered on the first day of the irradiation course, as opposed to the last day. Therefore, the MRT SIB should be integrated into a clinical radiotherapy schedule as early as possible. MDPI 2022-07-28 /pmc/articles/PMC9368396/ /pubmed/35955454 http://dx.doi.org/10.3390/ijms23158319 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jaekel, Felix
Bräuer-Krisch, Elke
Bartzsch, Stefan
Laissue, Jean
Blattmann, Hans
Scholz, Marten
Soloviova, Julia
Hildebrandt, Guido
Schültke, Elisabeth
Microbeam Irradiation as a Simultaneously Integrated Boost in a Conventional Whole-Brain Radiotherapy Protocol
title Microbeam Irradiation as a Simultaneously Integrated Boost in a Conventional Whole-Brain Radiotherapy Protocol
title_full Microbeam Irradiation as a Simultaneously Integrated Boost in a Conventional Whole-Brain Radiotherapy Protocol
title_fullStr Microbeam Irradiation as a Simultaneously Integrated Boost in a Conventional Whole-Brain Radiotherapy Protocol
title_full_unstemmed Microbeam Irradiation as a Simultaneously Integrated Boost in a Conventional Whole-Brain Radiotherapy Protocol
title_short Microbeam Irradiation as a Simultaneously Integrated Boost in a Conventional Whole-Brain Radiotherapy Protocol
title_sort microbeam irradiation as a simultaneously integrated boost in a conventional whole-brain radiotherapy protocol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368396/
https://www.ncbi.nlm.nih.gov/pubmed/35955454
http://dx.doi.org/10.3390/ijms23158319
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