Cargando…

Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development

There is an urgent need for analgesics with improved efficacy, especially in neuropathic and other chronic pain conditions. Unfortunately, in recent decades, many candidate analgesics have failed in clinical phase II or III trials despite promising preclinical results. Translational assessment tools...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Niel, Johannes, Bloms-Funke, Petra, Caspani, Ombretta, Cendros, Jose Maria, Garcia-Larrea, Luis, Truini, Andrea, Tracey, Irene, Chapman, Sonya C., Marco-Ariño, Nicolás, Troconiz, Iñaki F., Phillips, Keith, Finnerup, Nanna Brix, Mouraux, André, Treede, Rolf-Detlef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368481/ https://www.ncbi.nlm.nih.gov/pubmed/35955432 http://dx.doi.org/10.3390/ijms23158295

Ejemplares similares

IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG)
por: Mouraux, André, et al.
Publicado: (2021)

Human surrogate models of central sensitization: A critical review and practical guide
por: Quesada, Charles, et al.
Publicado: (2021)

IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity
por: Leone, Caterina, et al.
Publicado: (2022)

IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET)
por: Nochi, Zahra, et al.
Publicado: (2022)

The test–retest reliability of large and small fiber nerve excitability testing with threshold tracking
por: Pia, Hossein, et al.
Publicado: (2023)

Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans
por: Di Lionardo, A., et al.
Publicado: (2021)

Trigeminal neuralgia: New classification and diagnostic grading for practice and research
por: Cruccu, Giorgio, et al.
Publicado: (2016)

Organization of the Thermal Grill Illusion by Spinal Segments
por: Fardo, Francesca, et al.
Publicado: (2018)

Recent advances in pharmacological treatment of neuropathic pain
por: Finnerup, Nanna Brix, et al.
Publicado: (2010)

Cycloartanes from Oxyanthus pallidus and derivatives with analgesic activities
por: Piegang, Basile Nganmegne, et al.
Publicado: (2016)

Abdominal Pain: A Comparison between Neurogenic Bowel Dysfunction and Chronic Idiopathic Constipation
por: Faaborg, Pia Møller, et al.
Publicado: (2013)

The International Association for the Study of Pain definition of pain: as valid in 2018 as in 1979, but in need of regularly updated footnotes
por: Treede, Rolf-Detlef
Publicado: (2018)

Chronic musculoskeletal pain: traps and pitfalls in classification and management of a major global disease burden
por: Treede, Rolf-Detlef
Publicado: (2022)

Delta and gamma oscillations in operculo-insular cortex underlie innocuous cold thermosensation
por: Fardo, Francesca, et al.
Publicado: (2017)

No association of polymorphisms in the serotonin transporter gene with thermal pain sensation in healthy individuals
por: Schaldemose, Ellen Lund, et al.
Publicado: (2014)

TRPA1 and Cold Transduction: An Unresolved Issue?
por: Caspani, Ombretta, et al.
Publicado: (2009)

Clinical use of pregabalin in the management of central neuropathic pain
por: Finnerup, Nanna B, et al.
Publicado: (2007)

Reliability and Validity of the International Spinal Cord Injury Basic Pain Dataset Items as Self-Report Measures
por: Jensen, Mark P., et al.
Publicado: (2009)

Persistent Pain and Sensory Abnormalities after Abdominoplasty
por: Presman, Benjamin, et al.
Publicado: (2015)

Neuropathic pain: an updated grading system for research and clinical practice
por: Finnerup, Nanna B., et al.
Publicado: (2016)

Assessment of pain quality reveals distinct differences between nociceptive innervation of low back fascia and muscle in humans
por: Schilder, Andreas, et al.
Publicado: (2018)

Evaluation of the International Classification of Diseases-11 chronic pain classification: study protocol for an ecological implementation field study in low-, middle-, and high-income countries
por: Korwisi, Beatrice, et al.
Publicado: (2020)

Dose-Dependent Pain and Pain Radiation after Chemical Stimulation of the Thoracolumbar Fascia and Multifidus Muscle: A Single-Blinded, Cross-Over Study Revealing a Higher Impact of Fascia Stimulation
por: Vogel, Simon, et al.
Publicado: (2022)

Temporal and spatial summation of laser heat stimuli in cultured nociceptive neurons of the rat
por: Jubileum, Elisabeth, et al.
Publicado: (2022)

Sleep Deprivation Related Changes of Plasma Oxytocin in Males and Female Contraceptive Users Depend on Sex and Correlate Differentially With Anxiety and Pain Hypersensitivity
por: Schuh-Hofer, Sigrid, et al.
Publicado: (2018)

The capsaicin receptor TRPV1 is the first line defense protecting from acute non damaging heat: a translational approach
por: Rosenberger, Daniela C., et al.
Publicado: (2020)

Rat dorsal horn neurons primed by stress develop a long-lasting manifest sensitization after a short-lasting nociceptive low back input
por: Singaravelu, Sathish Kumar, et al.
Publicado: (2021)

Mechanical Punctate Pain Thresholds in Patients With Migraine Across Different Migraine Phases: A Narrative Review
por: Pan, Li-Ling Hope, et al.
Publicado: (2022)

Polymorphism in Serotonin Receptor 3B Is Associated with Pain Catastrophizing
por: Horjales-Araujo, Emilia, et al.
Publicado: (2013)

Natural history of pain associated with melanoma surgery
por: Slagelse, Charlotte, et al.
Publicado: (2018)

Can diabetic polyneuropathy and foot ulcers in patients with type 2 diabetes be accurately identified based on ICD-10 hospital diagnoses and drug prescriptions?
por: Christensen, Diana Hedevang, et al.
Publicado: (2019)

The Contribution of TRPM8 and TRPA1 Channels to Cold Allodynia and Neuropathic Pain
por: Caspani, Ombretta, et al.
Publicado: (2009)

Challenges of neuropathic pain: focus on diabetic neuropathy
por: Rosenberger, Daniela C., et al.
Publicado: (2020)

Projektbericht zur Förderung wissenschaftlicher Kompetenzen im Fach Schmerzmedizin im Rahmen der curricularen Lehre
por: Dusch, Martin, et al.
Publicado: (2022)

Classification of chronic pain for the International Classification of Diseases (ICD-11): results of the 2017 international World Health Organization field testing
por: Barke, Antonia, et al.
Publicado: (2022)

Analysis of Macrophages and Peptidergic Fibers in the Skin of Patients With Painful Diabetic Polyneuropathy
por: Gylfadottir, Sandra Sif, et al.
Publicado: (2021)

Pain Following Stroke: A Population-Based Follow-Up Study
por: Klit, Henriette, et al.
Publicado: (2011)

Detection of central circuits implicated in the formation of novel pain memories
por: Upadhyay, Jaymin, et al.
Publicado: (2016)

Tenderness of the Skin after Chemical Stimulation of Underlying Temporal and Thoracolumbar Fasciae Reveals Somatosensory Crosstalk between Superficial and Deep Tissues
por: Magerl, Walter, et al.
Publicado: (2021)

Noxious radiant heat evokes bi-component nociceptive withdrawal reflexes in spinal cord injured humans—A clinical tool to study neuroplastic changes of spinal neural circuits
por: Franz, Steffen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8n8qknbbta586u0e5kn6vq7r18