Discovery of Novel HSP27 Inhibitors as Prospective Anti-Cancer Agents Utilizing Computer-Assisted Therapeutic Discovery Approaches

Heat shock protein 27 (HSP27) is a protein that works as a chaperone and an antioxidant and is activated by heat shock, environmental stress, and pathophysiological stress. However, HSP27 dysregulation is a characteristic of many human cancers. HSP27 suppresses apoptosis and cytoskeletal reorganizat...

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Detalles Bibliográficos
Autores principales: Umar, Haruna Isiyaku, Ajayi, Adeola Temitayo, Mukerjee, Nobendu, Aborode, Abdullahi Tunde, Hasan, Mohammad Mehedi, Maitra, Swastika, Bello, Ridwan O., Alabere, Hafsat O., Sanusi, Afees A., Awolaja, Olamide O., Alshehri, Mohammed M., Chukwuemeka, Prosper O., Aljarba, Nada H., Alkahtani, Saad, Malik, Sumira, Alexiou, Athanasios, Ghosh, Arabinda, Rahman, Md. Habibur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368632/
https://www.ncbi.nlm.nih.gov/pubmed/35954254
http://dx.doi.org/10.3390/cells11152412

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