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The Role of Platelets in Diabetic Kidney Disease

Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory...

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Detalles Bibliográficos
Autores principales: Rustiasari, Ukhti Jamil, Roelofs, Joris J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368651/
https://www.ncbi.nlm.nih.gov/pubmed/35955405
http://dx.doi.org/10.3390/ijms23158270
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author Rustiasari, Ukhti Jamil
Roelofs, Joris J.
author_facet Rustiasari, Ukhti Jamil
Roelofs, Joris J.
author_sort Rustiasari, Ukhti Jamil
collection PubMed
description Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory and coagulation processes. Activated platelets play a pivotal role in inflammation, coagulation, and fibrosis. Mounting evidence shows that platelets play a role in the pathogenesis and progression of DKD. The potentially beneficial effects of antiplatelet agents in preventing progression of DKD has been studied in animal models and clinical trials. This review summarizes the current knowledge on the role of platelets in DKD, including the potential therapeutic effects of antiplatelet therapies.
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spelling pubmed-93686512022-08-12 The Role of Platelets in Diabetic Kidney Disease Rustiasari, Ukhti Jamil Roelofs, Joris J. Int J Mol Sci Review Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory and coagulation processes. Activated platelets play a pivotal role in inflammation, coagulation, and fibrosis. Mounting evidence shows that platelets play a role in the pathogenesis and progression of DKD. The potentially beneficial effects of antiplatelet agents in preventing progression of DKD has been studied in animal models and clinical trials. This review summarizes the current knowledge on the role of platelets in DKD, including the potential therapeutic effects of antiplatelet therapies. MDPI 2022-07-27 /pmc/articles/PMC9368651/ /pubmed/35955405 http://dx.doi.org/10.3390/ijms23158270 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rustiasari, Ukhti Jamil
Roelofs, Joris J.
The Role of Platelets in Diabetic Kidney Disease
title The Role of Platelets in Diabetic Kidney Disease
title_full The Role of Platelets in Diabetic Kidney Disease
title_fullStr The Role of Platelets in Diabetic Kidney Disease
title_full_unstemmed The Role of Platelets in Diabetic Kidney Disease
title_short The Role of Platelets in Diabetic Kidney Disease
title_sort role of platelets in diabetic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368651/
https://www.ncbi.nlm.nih.gov/pubmed/35955405
http://dx.doi.org/10.3390/ijms23158270
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