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The Role of Platelets in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368651/ https://www.ncbi.nlm.nih.gov/pubmed/35955405 http://dx.doi.org/10.3390/ijms23158270 |
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author | Rustiasari, Ukhti Jamil Roelofs, Joris J. |
author_facet | Rustiasari, Ukhti Jamil Roelofs, Joris J. |
author_sort | Rustiasari, Ukhti Jamil |
collection | PubMed |
description | Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory and coagulation processes. Activated platelets play a pivotal role in inflammation, coagulation, and fibrosis. Mounting evidence shows that platelets play a role in the pathogenesis and progression of DKD. The potentially beneficial effects of antiplatelet agents in preventing progression of DKD has been studied in animal models and clinical trials. This review summarizes the current knowledge on the role of platelets in DKD, including the potential therapeutic effects of antiplatelet therapies. |
format | Online Article Text |
id | pubmed-9368651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93686512022-08-12 The Role of Platelets in Diabetic Kidney Disease Rustiasari, Ukhti Jamil Roelofs, Joris J. Int J Mol Sci Review Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory and coagulation processes. Activated platelets play a pivotal role in inflammation, coagulation, and fibrosis. Mounting evidence shows that platelets play a role in the pathogenesis and progression of DKD. The potentially beneficial effects of antiplatelet agents in preventing progression of DKD has been studied in animal models and clinical trials. This review summarizes the current knowledge on the role of platelets in DKD, including the potential therapeutic effects of antiplatelet therapies. MDPI 2022-07-27 /pmc/articles/PMC9368651/ /pubmed/35955405 http://dx.doi.org/10.3390/ijms23158270 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rustiasari, Ukhti Jamil Roelofs, Joris J. The Role of Platelets in Diabetic Kidney Disease |
title | The Role of Platelets in Diabetic Kidney Disease |
title_full | The Role of Platelets in Diabetic Kidney Disease |
title_fullStr | The Role of Platelets in Diabetic Kidney Disease |
title_full_unstemmed | The Role of Platelets in Diabetic Kidney Disease |
title_short | The Role of Platelets in Diabetic Kidney Disease |
title_sort | role of platelets in diabetic kidney disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368651/ https://www.ncbi.nlm.nih.gov/pubmed/35955405 http://dx.doi.org/10.3390/ijms23158270 |
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