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Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment

Stroke is the leading cause of death and neurological disorders worldwide. However, diagnostic techniques and treatments for stroke patients are still limited for certain types of stroke. Intensive research has been conducted so far to find suitable diagnostic techniques and treatments, but so far t...

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Autores principales: Lee, Eun Chae, Ha, Tae Won, Lee, Dong-Hun, Hong, Dong-Yong, Park, Sang-Won, Lee, Ji Young, Lee, Man Ryul, Oh, Jae Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368737/
https://www.ncbi.nlm.nih.gov/pubmed/35955498
http://dx.doi.org/10.3390/ijms23158367
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author Lee, Eun Chae
Ha, Tae Won
Lee, Dong-Hun
Hong, Dong-Yong
Park, Sang-Won
Lee, Ji Young
Lee, Man Ryul
Oh, Jae Sang
author_facet Lee, Eun Chae
Ha, Tae Won
Lee, Dong-Hun
Hong, Dong-Yong
Park, Sang-Won
Lee, Ji Young
Lee, Man Ryul
Oh, Jae Sang
author_sort Lee, Eun Chae
collection PubMed
description Stroke is the leading cause of death and neurological disorders worldwide. However, diagnostic techniques and treatments for stroke patients are still limited for certain types of stroke. Intensive research has been conducted so far to find suitable diagnostic techniques and treatments, but so far there has been no success. In recent years, various studies have drawn much attention to the clinical value of utilizing the mechanism of exosomes, low toxicity, biodegradability, and the ability to cross the blood–brain barrier. Recent studies have been reported on the use of biomarkers and protective and recovery effects of exosomes derived from stem cells or various cells in the diagnostic stage after stroke. This review focuses on publications describing changes in diagnostic biomarkers of exosomes following various strokes and processes for various potential applications as therapeutics.
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spelling pubmed-93687372022-08-12 Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment Lee, Eun Chae Ha, Tae Won Lee, Dong-Hun Hong, Dong-Yong Park, Sang-Won Lee, Ji Young Lee, Man Ryul Oh, Jae Sang Int J Mol Sci Review Stroke is the leading cause of death and neurological disorders worldwide. However, diagnostic techniques and treatments for stroke patients are still limited for certain types of stroke. Intensive research has been conducted so far to find suitable diagnostic techniques and treatments, but so far there has been no success. In recent years, various studies have drawn much attention to the clinical value of utilizing the mechanism of exosomes, low toxicity, biodegradability, and the ability to cross the blood–brain barrier. Recent studies have been reported on the use of biomarkers and protective and recovery effects of exosomes derived from stem cells or various cells in the diagnostic stage after stroke. This review focuses on publications describing changes in diagnostic biomarkers of exosomes following various strokes and processes for various potential applications as therapeutics. MDPI 2022-07-28 /pmc/articles/PMC9368737/ /pubmed/35955498 http://dx.doi.org/10.3390/ijms23158367 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee, Eun Chae
Ha, Tae Won
Lee, Dong-Hun
Hong, Dong-Yong
Park, Sang-Won
Lee, Ji Young
Lee, Man Ryul
Oh, Jae Sang
Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment
title Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment
title_full Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment
title_fullStr Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment
title_full_unstemmed Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment
title_short Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment
title_sort utility of exosomes in ischemic and hemorrhagic stroke diagnosis and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368737/
https://www.ncbi.nlm.nih.gov/pubmed/35955498
http://dx.doi.org/10.3390/ijms23158367
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