The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination

The cytotoxic action of anticancer drugs can be potentiated by inhibiting DNA repair mechanisms. RAD51 is a crucial protein for genomic stability due to its critical role in the homologous recombination (HR) pathway. BRCA2 assists RAD51 fibrillation and defibrillation in the cytoplasm and nucleus an...

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Detalles Bibliográficos
Autores principales: Schipani, Fabrizio, Manerba, Marcella, Marotta, Roberto, Poppi, Laura, Gennari, Arianna, Rinaldi, Francesco, Armirotti, Andrea, Farabegoli, Fulvia, Roberti, Marinella, Di Stefano, Giuseppina, Rocchia, Walter, Girotto, Stefania, Tirelli, Nicola, Cavalli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368738/
https://www.ncbi.nlm.nih.gov/pubmed/35955488
http://dx.doi.org/10.3390/ijms23158338

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