Cargando…

Neuropilin (NRPs) Related Pathological Conditions and Their Modulators

Neuropilin 1 (NRP1) represents one of the two homologous neuropilins (NRP, splice variants of neuropilin 2 are the other) found in all vertebrates. It forms a transmembrane glycoprotein distributed in many human body tissues as a (co)receptor for a variety of different ligands. In addition to its ph...

Descripción completa

Detalles Bibliográficos
Autores principales: Broz, Matic, Kolarič, Anja, Jukič, Marko, Bren, Urban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368954/
https://www.ncbi.nlm.nih.gov/pubmed/35955539
http://dx.doi.org/10.3390/ijms23158402
_version_ 1784766304863911936
author Broz, Matic
Kolarič, Anja
Jukič, Marko
Bren, Urban
author_facet Broz, Matic
Kolarič, Anja
Jukič, Marko
Bren, Urban
author_sort Broz, Matic
collection PubMed
description Neuropilin 1 (NRP1) represents one of the two homologous neuropilins (NRP, splice variants of neuropilin 2 are the other) found in all vertebrates. It forms a transmembrane glycoprotein distributed in many human body tissues as a (co)receptor for a variety of different ligands. In addition to its physiological role, it is also associated with various pathological conditions. Recently, NRP1 has been discovered as a coreceptor for the SARS-CoV-2 viral entry, along with ACE2, and has thus become one of the COVID-19 research foci. However, in addition to COVID-19, the current review also summarises its other pathological roles and its involvement in clinical diseases like cancer and neuropathic pain. We also discuss the diversity of native NRP ligands and perform a joint analysis. Last but not least, we review the therapeutic roles of NRP1 and introduce a series of NRP1 modulators, which are typical peptidomimetics or other small molecule antagonists, to provide the medicinal chemistry community with a state-of-the-art overview of neuropilin modulator design and NRP1 druggability assessment.
format Online
Article
Text
id pubmed-9368954
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93689542022-08-12 Neuropilin (NRPs) Related Pathological Conditions and Their Modulators Broz, Matic Kolarič, Anja Jukič, Marko Bren, Urban Int J Mol Sci Review Neuropilin 1 (NRP1) represents one of the two homologous neuropilins (NRP, splice variants of neuropilin 2 are the other) found in all vertebrates. It forms a transmembrane glycoprotein distributed in many human body tissues as a (co)receptor for a variety of different ligands. In addition to its physiological role, it is also associated with various pathological conditions. Recently, NRP1 has been discovered as a coreceptor for the SARS-CoV-2 viral entry, along with ACE2, and has thus become one of the COVID-19 research foci. However, in addition to COVID-19, the current review also summarises its other pathological roles and its involvement in clinical diseases like cancer and neuropathic pain. We also discuss the diversity of native NRP ligands and perform a joint analysis. Last but not least, we review the therapeutic roles of NRP1 and introduce a series of NRP1 modulators, which are typical peptidomimetics or other small molecule antagonists, to provide the medicinal chemistry community with a state-of-the-art overview of neuropilin modulator design and NRP1 druggability assessment. MDPI 2022-07-29 /pmc/articles/PMC9368954/ /pubmed/35955539 http://dx.doi.org/10.3390/ijms23158402 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Broz, Matic
Kolarič, Anja
Jukič, Marko
Bren, Urban
Neuropilin (NRPs) Related Pathological Conditions and Their Modulators
title Neuropilin (NRPs) Related Pathological Conditions and Their Modulators
title_full Neuropilin (NRPs) Related Pathological Conditions and Their Modulators
title_fullStr Neuropilin (NRPs) Related Pathological Conditions and Their Modulators
title_full_unstemmed Neuropilin (NRPs) Related Pathological Conditions and Their Modulators
title_short Neuropilin (NRPs) Related Pathological Conditions and Their Modulators
title_sort neuropilin (nrps) related pathological conditions and their modulators
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368954/
https://www.ncbi.nlm.nih.gov/pubmed/35955539
http://dx.doi.org/10.3390/ijms23158402
work_keys_str_mv AT brozmatic neuropilinnrpsrelatedpathologicalconditionsandtheirmodulators
AT kolaricanja neuropilinnrpsrelatedpathologicalconditionsandtheirmodulators
AT jukicmarko neuropilinnrpsrelatedpathologicalconditionsandtheirmodulators
AT brenurban neuropilinnrpsrelatedpathologicalconditionsandtheirmodulators