Quantum Biochemistry Screening and In Vitro Evaluation of Leishmania Metalloproteinase Inhibitors

Leishmanolysin, also known as major promastigote protease (PSP) or gp63, is the most abundant surface glycoprotein of Leishmania spp., and has been extensively studied and recognized as the main parasite virulence factor. Characterized as a metalloprotease, gp63 can be powerfully inactivated in the...

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Detalles Bibliográficos
Autores principales: Moreno, Cláudia Jassica Gonçalves, Farias, Henriqueta Monalisa, de Lima Medeiros, Rafael, de Brito Pinto, Talita Katiane, de Freitas Oliveira, Johny Wysllas, de Sousa, Francimar Lopes, de Medeiros, Mayara Jane Campos, Amorim-Carmo, Bruno, Santos-Gomes, Gabriela, de Lima Pontes, Daniel, Rocha, Hugo Alexandre Oliveira, Frazão, Nilton Fereira, Silva, Marcelo Sousa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368959/
https://www.ncbi.nlm.nih.gov/pubmed/35955687
http://dx.doi.org/10.3390/ijms23158553

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