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Promiscuous Lipase-Catalyzed Knoevenagel–Phospha–Michael Reaction for the Synthesis of Antimicrobial β-Phosphono Malonates

An enzymatic route for phosphorous–carbon bond formation was developed by discovering new promiscuous activity of lipase. We reported a new metal-free biocatalytic method for the synthesis of pharmacologically relevant β-phosphonomalononitriles via a lipase-catalyzed one-pot Knoevenagel–phospha–Mich...

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Detalles Bibliográficos
Autores principales:	Samsonowicz-Górski, Jan, Koszelewski, Dominik, Kowalczyk, Paweł, Śmigielski, Paweł, Hrunyk, Anastasiia, Kramkowski, Karol, Wypych, Aleksandra, Szymczak, Mateusz, Lizut, Rafał, Ostaszewski, Ryszard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368977/ https://www.ncbi.nlm.nih.gov/pubmed/35955950 http://dx.doi.org/10.3390/ijms23158819

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