An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study

Atopic eczema (AE) is an inflammatory skin disorder affecting approximately 20% of children worldwide and early onset can lead to asthma and allergies. Currently, the mechanisms of the disease are not fully understood. Metabolomics, the analysis of small molecules in the skin produced by the host an...

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Autores principales: Afghani, Jamie, Traidl-Hoffmann, Claudia, Schmitt-Kopplin, Philippe, Reiger, Matthias, Mueller, Constanze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368995/
https://www.ncbi.nlm.nih.gov/pubmed/35955924
http://dx.doi.org/10.3390/ijms23158791
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author Afghani, Jamie
Traidl-Hoffmann, Claudia
Schmitt-Kopplin, Philippe
Reiger, Matthias
Mueller, Constanze
author_facet Afghani, Jamie
Traidl-Hoffmann, Claudia
Schmitt-Kopplin, Philippe
Reiger, Matthias
Mueller, Constanze
author_sort Afghani, Jamie
collection PubMed
description Atopic eczema (AE) is an inflammatory skin disorder affecting approximately 20% of children worldwide and early onset can lead to asthma and allergies. Currently, the mechanisms of the disease are not fully understood. Metabolomics, the analysis of small molecules in the skin produced by the host and microbes, opens a window to observe the mechanisms of the disease which then may lead to new drug targets for AE treatment. Here, we review the latest advances in AE metabolomics, highlighting both the lipid and non-lipid molecules, along with reviewing the metabolites currently known to reside in the skin.
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spelling pubmed-93689952022-08-12 An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study Afghani, Jamie Traidl-Hoffmann, Claudia Schmitt-Kopplin, Philippe Reiger, Matthias Mueller, Constanze Int J Mol Sci Review Atopic eczema (AE) is an inflammatory skin disorder affecting approximately 20% of children worldwide and early onset can lead to asthma and allergies. Currently, the mechanisms of the disease are not fully understood. Metabolomics, the analysis of small molecules in the skin produced by the host and microbes, opens a window to observe the mechanisms of the disease which then may lead to new drug targets for AE treatment. Here, we review the latest advances in AE metabolomics, highlighting both the lipid and non-lipid molecules, along with reviewing the metabolites currently known to reside in the skin. MDPI 2022-08-08 /pmc/articles/PMC9368995/ /pubmed/35955924 http://dx.doi.org/10.3390/ijms23158791 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Afghani, Jamie
Traidl-Hoffmann, Claudia
Schmitt-Kopplin, Philippe
Reiger, Matthias
Mueller, Constanze
An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study
title An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study
title_full An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study
title_fullStr An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study
title_full_unstemmed An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study
title_short An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study
title_sort overview of the latest metabolomics studies on atopic eczema with new directions for study
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368995/
https://www.ncbi.nlm.nih.gov/pubmed/35955924
http://dx.doi.org/10.3390/ijms23158791
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