Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2

Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain transcending virus neutralizing activity. SARS-CoV-2 neutralization and Fc-effector functions of ACE2-Fc decoy proteins, formatted with or without the ACE2 collectrin dom...

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Detalles Bibliográficos
Autores principales: Wines, Bruce D., Kurtovic, Liriye, Trist, Halina M., Esparon, Sandra, Lopez, Ester, Chappin, Klasina, Chan, Li-Jin, Mordant, Francesca L., Lee, Wen Shi, Gherardin, Nicholas A., Patel, Sheila K., Hartley, Gemma E., Pymm, Phillip, Cooney, James P., Beeson, James G., Godfrey, Dale I., Burrell, Louise M., van Zelm, Menno C., Wheatley, Adam K., Chung, Amy W., Tham, Wai-Hong, Subbarao, Kanta, Kent, Stephen J., Hogarth, P. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369017/
https://www.ncbi.nlm.nih.gov/pubmed/35967361
http://dx.doi.org/10.3389/fimmu.2022.889372

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