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Cortical and Subcortical Alterations and Clinical Correlates after Traumatic Brain Injury

Background: Traumatic brain injury (TBI) often results in persistent cognitive impairment and psychiatric symptoms, while lesion location and severity are not consistent with its clinical complaints. Previous studies found cognitive deficits and psychiatric disorders following TBI are considered to...

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Autores principales: Xue, Qiang, Wang, Linbo, Zhao, Yuanyu, Tong, Wusong, Wang, Jiancun, Li, Gaoyi, Cheng, Wei, Gao, Liang, Dong, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369032/
https://www.ncbi.nlm.nih.gov/pubmed/35956036
http://dx.doi.org/10.3390/jcm11154421
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author Xue, Qiang
Wang, Linbo
Zhao, Yuanyu
Tong, Wusong
Wang, Jiancun
Li, Gaoyi
Cheng, Wei
Gao, Liang
Dong, Yan
author_facet Xue, Qiang
Wang, Linbo
Zhao, Yuanyu
Tong, Wusong
Wang, Jiancun
Li, Gaoyi
Cheng, Wei
Gao, Liang
Dong, Yan
author_sort Xue, Qiang
collection PubMed
description Background: Traumatic brain injury (TBI) often results in persistent cognitive impairment and psychiatric symptoms, while lesion location and severity are not consistent with its clinical complaints. Previous studies found cognitive deficits and psychiatric disorders following TBI are considered to be associated with prefrontal and medial temporal lobe lesions, however, the location and extent of contusions often cannot fully explain the patient′s impairments. Thus, we try to find the structural changes of gray matter (GM) and white matter (WM), clarify their correlation with psychiatric symptoms and memory following TBI, and determine the brain regions that primary correlate with clinical measurements. Methods: Overall, 32 TBI individuals and 23 healthy controls were recruited in the study. Cognitive impairment and psychiatric symptoms were examined by Mini-Mental State Examination (MMSE), Hospital Anxiety and Depression Scale (HADS), and Wechsler Memory Scale-Chinese Revision (WMS-CR). All MRI data were scanned using a Siemens Prisma 3.0 Tesla MRI system. T1 MRI data and diffusion tensor imaging (DTI) data were processed to analyze GM volume and WM microstructure separately. Results: In the present study, TBI patients underwent widespread decrease of GM volume in both cortical and subcortical regions. Among these regions, four brain areas including the left inferior temporal gyrus and medial temporal lobe, supplementary motor area, thalamus, and anterior cingulate cortex (ACC) were highly implicated in the post-traumatic cognitive impairment and psychiatric complaints. TBI patients also underwent changes of WM microstructure, involving decreased fractional anisotropy (FA) value in widespread WM tracts and increased mean diffusivity (MD) value in the forceps minor. The changes of WM microstructure were significantly correlated with the decrease of GM volume. Conclusions: TBI causes widespread cortical and subcortical alterations including a reduction in GM volume and change in WM microstructure related to clinical manifestation. Lesions in temporal lobe may lead to more serious cognitive and emotional dysfunction, which should attract our high clinical attention.
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spelling pubmed-93690322022-08-12 Cortical and Subcortical Alterations and Clinical Correlates after Traumatic Brain Injury Xue, Qiang Wang, Linbo Zhao, Yuanyu Tong, Wusong Wang, Jiancun Li, Gaoyi Cheng, Wei Gao, Liang Dong, Yan J Clin Med Article Background: Traumatic brain injury (TBI) often results in persistent cognitive impairment and psychiatric symptoms, while lesion location and severity are not consistent with its clinical complaints. Previous studies found cognitive deficits and psychiatric disorders following TBI are considered to be associated with prefrontal and medial temporal lobe lesions, however, the location and extent of contusions often cannot fully explain the patient′s impairments. Thus, we try to find the structural changes of gray matter (GM) and white matter (WM), clarify their correlation with psychiatric symptoms and memory following TBI, and determine the brain regions that primary correlate with clinical measurements. Methods: Overall, 32 TBI individuals and 23 healthy controls were recruited in the study. Cognitive impairment and psychiatric symptoms were examined by Mini-Mental State Examination (MMSE), Hospital Anxiety and Depression Scale (HADS), and Wechsler Memory Scale-Chinese Revision (WMS-CR). All MRI data were scanned using a Siemens Prisma 3.0 Tesla MRI system. T1 MRI data and diffusion tensor imaging (DTI) data were processed to analyze GM volume and WM microstructure separately. Results: In the present study, TBI patients underwent widespread decrease of GM volume in both cortical and subcortical regions. Among these regions, four brain areas including the left inferior temporal gyrus and medial temporal lobe, supplementary motor area, thalamus, and anterior cingulate cortex (ACC) were highly implicated in the post-traumatic cognitive impairment and psychiatric complaints. TBI patients also underwent changes of WM microstructure, involving decreased fractional anisotropy (FA) value in widespread WM tracts and increased mean diffusivity (MD) value in the forceps minor. The changes of WM microstructure were significantly correlated with the decrease of GM volume. Conclusions: TBI causes widespread cortical and subcortical alterations including a reduction in GM volume and change in WM microstructure related to clinical manifestation. Lesions in temporal lobe may lead to more serious cognitive and emotional dysfunction, which should attract our high clinical attention. MDPI 2022-07-29 /pmc/articles/PMC9369032/ /pubmed/35956036 http://dx.doi.org/10.3390/jcm11154421 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xue, Qiang
Wang, Linbo
Zhao, Yuanyu
Tong, Wusong
Wang, Jiancun
Li, Gaoyi
Cheng, Wei
Gao, Liang
Dong, Yan
Cortical and Subcortical Alterations and Clinical Correlates after Traumatic Brain Injury
title Cortical and Subcortical Alterations and Clinical Correlates after Traumatic Brain Injury
title_full Cortical and Subcortical Alterations and Clinical Correlates after Traumatic Brain Injury
title_fullStr Cortical and Subcortical Alterations and Clinical Correlates after Traumatic Brain Injury
title_full_unstemmed Cortical and Subcortical Alterations and Clinical Correlates after Traumatic Brain Injury
title_short Cortical and Subcortical Alterations and Clinical Correlates after Traumatic Brain Injury
title_sort cortical and subcortical alterations and clinical correlates after traumatic brain injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369032/
https://www.ncbi.nlm.nih.gov/pubmed/35956036
http://dx.doi.org/10.3390/jcm11154421
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