Kaposi’s Sarcoma-Associated Herpesvirus ORF50 Protein Represses Cellular MDM2 Expression via Suppressing the Sp1- and p53-Mediated Transactivation

The Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded ORF50 protein is a potent transcriptional activator essential for triggering KSHV lytic reactivation. Despite extensive studies, little is known about whether ORF50 possesses the ability to repress gene expression or has an antagonistic acti...

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Detalles Bibliográficos
Autores principales: Lin, Chia-I, Wang, Shie-Shan, Hung, Chien-Hui, Chang, Pey-Jium, Chen, Lee-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369062/
https://www.ncbi.nlm.nih.gov/pubmed/35955808
http://dx.doi.org/10.3390/ijms23158673

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