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Polyploidy as an Adaptation against Loss of Heterozygosity in Cancer
Polyploidy is common in cancer cells and has implications for tumor progression and resistance to therapies, but it is unclear whether it is an adaptation of the tumor or the non-adaptive effect of genomic instability. I discuss the possibility that polyploidy reduces the deleterious effects of loss...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369199/ https://www.ncbi.nlm.nih.gov/pubmed/35955663 http://dx.doi.org/10.3390/ijms23158528 |