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mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
Decreased content and activity of the mechanistic target of rapamycin (mTOR) signalling pathway, as well as the mTOR complex 1 (mTORC1) itself, are key traits for animal species and human longevity. Since mTORC1 acts as a master regulator of intracellular metabolism, it is responsible, at least in p...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369240/ https://www.ncbi.nlm.nih.gov/pubmed/35955882 http://dx.doi.org/10.3390/ijms23158747 |
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author | Mota-Martorell, Natalia Jové, Mariona Pamplona, Reinald |
author_facet | Mota-Martorell, Natalia Jové, Mariona Pamplona, Reinald |
author_sort | Mota-Martorell, Natalia |
collection | PubMed |
description | Decreased content and activity of the mechanistic target of rapamycin (mTOR) signalling pathway, as well as the mTOR complex 1 (mTORC1) itself, are key traits for animal species and human longevity. Since mTORC1 acts as a master regulator of intracellular metabolism, it is responsible, at least in part, for the longevous phenotype. Conversely, increased content and activity of mTOR signalling and mTORC1 are hallmarks of ageing. Additionally, constitutive and aberrant activity of mTORC1 is also found in age-related diseases such as Alzheimer’s disease (AD) and cancer. The downstream processes regulated through this network are diverse, and depend upon nutrient availability. Hence, multiple nutritional strategies capable of regulating mTORC1 activity and, consequently, delaying the ageing process and the development of age-related diseases, are under continuous study. Among these, the restriction of calories is still the most studied and robust intervention capable of downregulating mTOR signalling and feasible for application in the human population. |
format | Online Article Text |
id | pubmed-9369240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93692402022-08-12 mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity Mota-Martorell, Natalia Jové, Mariona Pamplona, Reinald Int J Mol Sci Review Decreased content and activity of the mechanistic target of rapamycin (mTOR) signalling pathway, as well as the mTOR complex 1 (mTORC1) itself, are key traits for animal species and human longevity. Since mTORC1 acts as a master regulator of intracellular metabolism, it is responsible, at least in part, for the longevous phenotype. Conversely, increased content and activity of mTOR signalling and mTORC1 are hallmarks of ageing. Additionally, constitutive and aberrant activity of mTORC1 is also found in age-related diseases such as Alzheimer’s disease (AD) and cancer. The downstream processes regulated through this network are diverse, and depend upon nutrient availability. Hence, multiple nutritional strategies capable of regulating mTORC1 activity and, consequently, delaying the ageing process and the development of age-related diseases, are under continuous study. Among these, the restriction of calories is still the most studied and robust intervention capable of downregulating mTOR signalling and feasible for application in the human population. MDPI 2022-08-06 /pmc/articles/PMC9369240/ /pubmed/35955882 http://dx.doi.org/10.3390/ijms23158747 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mota-Martorell, Natalia Jové, Mariona Pamplona, Reinald mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity |
title | mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity |
title_full | mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity |
title_fullStr | mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity |
title_full_unstemmed | mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity |
title_short | mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity |
title_sort | mtor complex 1 content and regulation is adapted to animal longevity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369240/ https://www.ncbi.nlm.nih.gov/pubmed/35955882 http://dx.doi.org/10.3390/ijms23158747 |
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