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mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity

Decreased content and activity of the mechanistic target of rapamycin (mTOR) signalling pathway, as well as the mTOR complex 1 (mTORC1) itself, are key traits for animal species and human longevity. Since mTORC1 acts as a master regulator of intracellular metabolism, it is responsible, at least in p...

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Autores principales: Mota-Martorell, Natalia, Jové, Mariona, Pamplona, Reinald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369240/
https://www.ncbi.nlm.nih.gov/pubmed/35955882
http://dx.doi.org/10.3390/ijms23158747
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author Mota-Martorell, Natalia
Jové, Mariona
Pamplona, Reinald
author_facet Mota-Martorell, Natalia
Jové, Mariona
Pamplona, Reinald
author_sort Mota-Martorell, Natalia
collection PubMed
description Decreased content and activity of the mechanistic target of rapamycin (mTOR) signalling pathway, as well as the mTOR complex 1 (mTORC1) itself, are key traits for animal species and human longevity. Since mTORC1 acts as a master regulator of intracellular metabolism, it is responsible, at least in part, for the longevous phenotype. Conversely, increased content and activity of mTOR signalling and mTORC1 are hallmarks of ageing. Additionally, constitutive and aberrant activity of mTORC1 is also found in age-related diseases such as Alzheimer’s disease (AD) and cancer. The downstream processes regulated through this network are diverse, and depend upon nutrient availability. Hence, multiple nutritional strategies capable of regulating mTORC1 activity and, consequently, delaying the ageing process and the development of age-related diseases, are under continuous study. Among these, the restriction of calories is still the most studied and robust intervention capable of downregulating mTOR signalling and feasible for application in the human population.
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spelling pubmed-93692402022-08-12 mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity Mota-Martorell, Natalia Jové, Mariona Pamplona, Reinald Int J Mol Sci Review Decreased content and activity of the mechanistic target of rapamycin (mTOR) signalling pathway, as well as the mTOR complex 1 (mTORC1) itself, are key traits for animal species and human longevity. Since mTORC1 acts as a master regulator of intracellular metabolism, it is responsible, at least in part, for the longevous phenotype. Conversely, increased content and activity of mTOR signalling and mTORC1 are hallmarks of ageing. Additionally, constitutive and aberrant activity of mTORC1 is also found in age-related diseases such as Alzheimer’s disease (AD) and cancer. The downstream processes regulated through this network are diverse, and depend upon nutrient availability. Hence, multiple nutritional strategies capable of regulating mTORC1 activity and, consequently, delaying the ageing process and the development of age-related diseases, are under continuous study. Among these, the restriction of calories is still the most studied and robust intervention capable of downregulating mTOR signalling and feasible for application in the human population. MDPI 2022-08-06 /pmc/articles/PMC9369240/ /pubmed/35955882 http://dx.doi.org/10.3390/ijms23158747 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mota-Martorell, Natalia
Jové, Mariona
Pamplona, Reinald
mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
title mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
title_full mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
title_fullStr mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
title_full_unstemmed mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
title_short mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
title_sort mtor complex 1 content and regulation is adapted to animal longevity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369240/
https://www.ncbi.nlm.nih.gov/pubmed/35955882
http://dx.doi.org/10.3390/ijms23158747
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