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Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review

Among the difficulties of living with β-thalassemia, patients frequently require blood transfusions and experience iron overload. As serum ferritin (SF) provides an indication of potential iron overload, we conducted a systematic literature review (SLR) to assess whether SF levels are associated wit...

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Autores principales: Shah, Farrukh, Huey, Krystal, Deshpande, Sohan, Turner, Monica, Chitnis, Madhura, Schiller, Emma, Yucel, Aylin, Moro Bueno, Luciana, Oliva, Esther Natalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369259/
https://www.ncbi.nlm.nih.gov/pubmed/35956067
http://dx.doi.org/10.3390/jcm11154448
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author Shah, Farrukh
Huey, Krystal
Deshpande, Sohan
Turner, Monica
Chitnis, Madhura
Schiller, Emma
Yucel, Aylin
Moro Bueno, Luciana
Oliva, Esther Natalie
author_facet Shah, Farrukh
Huey, Krystal
Deshpande, Sohan
Turner, Monica
Chitnis, Madhura
Schiller, Emma
Yucel, Aylin
Moro Bueno, Luciana
Oliva, Esther Natalie
author_sort Shah, Farrukh
collection PubMed
description Among the difficulties of living with β-thalassemia, patients frequently require blood transfusions and experience iron overload. As serum ferritin (SF) provides an indication of potential iron overload, we conducted a systematic literature review (SLR) to assess whether SF levels are associated with clinical and economic burden and patient-reported outcomes (PROs). The SLR was conducted on 23 April 2020 and followed by analysis of the literature. Dual-screening was performed at the title, abstract, and full-text levels using predefined inclusion and exclusion criteria. Ten studies identified by the SLR were eligible for inclusion in the analysis. Seven studies were conducted in Europe, and most were prospective or retrospective in design. The patient populations had a median age of 20.7–42.6 years, with a percentage of men of 38–80%. Sparse data were found on the correlation between SF levels and mortality, and hepatic, skeletal, and cardiac complications; however, in general, higher SF levels were associated with worsened outcomes. The bulk of the evidence reported on the significant association between higher SF levels and endocrine dysfunction in its many presentations, including a 14-fold increase in the risk of diabetes for patients with persistently elevated SF levels. No studies reporting data on PROs or economic burden were identified by the SLR. SF levels provide another option for prognostic assessment to predict a range of clinical outcomes in patients with β-thalassemia.
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spelling pubmed-93692592022-08-12 Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review Shah, Farrukh Huey, Krystal Deshpande, Sohan Turner, Monica Chitnis, Madhura Schiller, Emma Yucel, Aylin Moro Bueno, Luciana Oliva, Esther Natalie J Clin Med Article Among the difficulties of living with β-thalassemia, patients frequently require blood transfusions and experience iron overload. As serum ferritin (SF) provides an indication of potential iron overload, we conducted a systematic literature review (SLR) to assess whether SF levels are associated with clinical and economic burden and patient-reported outcomes (PROs). The SLR was conducted on 23 April 2020 and followed by analysis of the literature. Dual-screening was performed at the title, abstract, and full-text levels using predefined inclusion and exclusion criteria. Ten studies identified by the SLR were eligible for inclusion in the analysis. Seven studies were conducted in Europe, and most were prospective or retrospective in design. The patient populations had a median age of 20.7–42.6 years, with a percentage of men of 38–80%. Sparse data were found on the correlation between SF levels and mortality, and hepatic, skeletal, and cardiac complications; however, in general, higher SF levels were associated with worsened outcomes. The bulk of the evidence reported on the significant association between higher SF levels and endocrine dysfunction in its many presentations, including a 14-fold increase in the risk of diabetes for patients with persistently elevated SF levels. No studies reporting data on PROs or economic burden were identified by the SLR. SF levels provide another option for prognostic assessment to predict a range of clinical outcomes in patients with β-thalassemia. MDPI 2022-07-30 /pmc/articles/PMC9369259/ /pubmed/35956067 http://dx.doi.org/10.3390/jcm11154448 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shah, Farrukh
Huey, Krystal
Deshpande, Sohan
Turner, Monica
Chitnis, Madhura
Schiller, Emma
Yucel, Aylin
Moro Bueno, Luciana
Oliva, Esther Natalie
Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review
title Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review
title_full Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review
title_fullStr Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review
title_full_unstemmed Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review
title_short Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review
title_sort relationship between serum ferritin and outcomes in β-thalassemia: a systematic literature review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369259/
https://www.ncbi.nlm.nih.gov/pubmed/35956067
http://dx.doi.org/10.3390/jcm11154448
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