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Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes

Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in physiological and different pathophysiological conditions. Ischemic stroke has a complex pathophysiology which includes perturbations in the brain energy metabolism processes which can contribute to wors...

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Autores principales: Sifat, Ali Ehsan, Nozohouri, Saeideh, Archie, Sabrina Rahman, Chowdhury, Ekram Ahmed, Abbruscato, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369264/
https://www.ncbi.nlm.nih.gov/pubmed/35955647
http://dx.doi.org/10.3390/ijms23158512
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author Sifat, Ali Ehsan
Nozohouri, Saeideh
Archie, Sabrina Rahman
Chowdhury, Ekram Ahmed
Abbruscato, Thomas J.
author_facet Sifat, Ali Ehsan
Nozohouri, Saeideh
Archie, Sabrina Rahman
Chowdhury, Ekram Ahmed
Abbruscato, Thomas J.
author_sort Sifat, Ali Ehsan
collection PubMed
description Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in physiological and different pathophysiological conditions. Ischemic stroke has a complex pathophysiology which includes perturbations in the brain energy metabolism processes which can contribute to worsening of brain injury and stroke outcome. Smoking and diabetes are common risk factors and comorbid conditions for ischemic stroke which have also been associated with disruptions in brain energy metabolism. Simultaneous presence of these conditions may further alter energy metabolism in the brain leading to a poor clinical prognosis after an ischemic stroke event. In this review, we discuss the possible effects of smoking and/or diabetes on brain glucose utilization and mitochondrial energy metabolism which, when present concurrently, may exacerbate energy metabolism in the ischemic brain. More research is needed to investigate brain glucose utilization and mitochondrial oxidative metabolism in ischemic stroke in the presence of smoking and/or diabetes, which would provide further insights on the pathophysiology of these comorbid conditions and facilitate the development of therapeutic interventions.
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spelling pubmed-93692642022-08-12 Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes Sifat, Ali Ehsan Nozohouri, Saeideh Archie, Sabrina Rahman Chowdhury, Ekram Ahmed Abbruscato, Thomas J. Int J Mol Sci Review Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in physiological and different pathophysiological conditions. Ischemic stroke has a complex pathophysiology which includes perturbations in the brain energy metabolism processes which can contribute to worsening of brain injury and stroke outcome. Smoking and diabetes are common risk factors and comorbid conditions for ischemic stroke which have also been associated with disruptions in brain energy metabolism. Simultaneous presence of these conditions may further alter energy metabolism in the brain leading to a poor clinical prognosis after an ischemic stroke event. In this review, we discuss the possible effects of smoking and/or diabetes on brain glucose utilization and mitochondrial energy metabolism which, when present concurrently, may exacerbate energy metabolism in the ischemic brain. More research is needed to investigate brain glucose utilization and mitochondrial oxidative metabolism in ischemic stroke in the presence of smoking and/or diabetes, which would provide further insights on the pathophysiology of these comorbid conditions and facilitate the development of therapeutic interventions. MDPI 2022-07-31 /pmc/articles/PMC9369264/ /pubmed/35955647 http://dx.doi.org/10.3390/ijms23158512 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sifat, Ali Ehsan
Nozohouri, Saeideh
Archie, Sabrina Rahman
Chowdhury, Ekram Ahmed
Abbruscato, Thomas J.
Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes
title Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes
title_full Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes
title_fullStr Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes
title_full_unstemmed Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes
title_short Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes
title_sort brain energy metabolism in ischemic stroke: effects of smoking and diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369264/
https://www.ncbi.nlm.nih.gov/pubmed/35955647
http://dx.doi.org/10.3390/ijms23158512
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