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Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes
Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in physiological and different pathophysiological conditions. Ischemic stroke has a complex pathophysiology which includes perturbations in the brain energy metabolism processes which can contribute to wors...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369264/ https://www.ncbi.nlm.nih.gov/pubmed/35955647 http://dx.doi.org/10.3390/ijms23158512 |
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author | Sifat, Ali Ehsan Nozohouri, Saeideh Archie, Sabrina Rahman Chowdhury, Ekram Ahmed Abbruscato, Thomas J. |
author_facet | Sifat, Ali Ehsan Nozohouri, Saeideh Archie, Sabrina Rahman Chowdhury, Ekram Ahmed Abbruscato, Thomas J. |
author_sort | Sifat, Ali Ehsan |
collection | PubMed |
description | Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in physiological and different pathophysiological conditions. Ischemic stroke has a complex pathophysiology which includes perturbations in the brain energy metabolism processes which can contribute to worsening of brain injury and stroke outcome. Smoking and diabetes are common risk factors and comorbid conditions for ischemic stroke which have also been associated with disruptions in brain energy metabolism. Simultaneous presence of these conditions may further alter energy metabolism in the brain leading to a poor clinical prognosis after an ischemic stroke event. In this review, we discuss the possible effects of smoking and/or diabetes on brain glucose utilization and mitochondrial energy metabolism which, when present concurrently, may exacerbate energy metabolism in the ischemic brain. More research is needed to investigate brain glucose utilization and mitochondrial oxidative metabolism in ischemic stroke in the presence of smoking and/or diabetes, which would provide further insights on the pathophysiology of these comorbid conditions and facilitate the development of therapeutic interventions. |
format | Online Article Text |
id | pubmed-9369264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93692642022-08-12 Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes Sifat, Ali Ehsan Nozohouri, Saeideh Archie, Sabrina Rahman Chowdhury, Ekram Ahmed Abbruscato, Thomas J. Int J Mol Sci Review Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in physiological and different pathophysiological conditions. Ischemic stroke has a complex pathophysiology which includes perturbations in the brain energy metabolism processes which can contribute to worsening of brain injury and stroke outcome. Smoking and diabetes are common risk factors and comorbid conditions for ischemic stroke which have also been associated with disruptions in brain energy metabolism. Simultaneous presence of these conditions may further alter energy metabolism in the brain leading to a poor clinical prognosis after an ischemic stroke event. In this review, we discuss the possible effects of smoking and/or diabetes on brain glucose utilization and mitochondrial energy metabolism which, when present concurrently, may exacerbate energy metabolism in the ischemic brain. More research is needed to investigate brain glucose utilization and mitochondrial oxidative metabolism in ischemic stroke in the presence of smoking and/or diabetes, which would provide further insights on the pathophysiology of these comorbid conditions and facilitate the development of therapeutic interventions. MDPI 2022-07-31 /pmc/articles/PMC9369264/ /pubmed/35955647 http://dx.doi.org/10.3390/ijms23158512 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sifat, Ali Ehsan Nozohouri, Saeideh Archie, Sabrina Rahman Chowdhury, Ekram Ahmed Abbruscato, Thomas J. Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes |
title | Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes |
title_full | Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes |
title_fullStr | Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes |
title_full_unstemmed | Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes |
title_short | Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes |
title_sort | brain energy metabolism in ischemic stroke: effects of smoking and diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369264/ https://www.ncbi.nlm.nih.gov/pubmed/35955647 http://dx.doi.org/10.3390/ijms23158512 |
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