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Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function
Glycoprotein (GP) VI is the major platelet collagen receptor and a promising anti-thrombotic target. This was first demonstrated in mice using the rat monoclonal antibody JAQ1, which completely blocks the Collagen-Related Peptide (CRP)-binding site on mouse GPVI and efficiently inhibits mouse platel...
Autores principales: | Navarro, Stefano, Starke, Andreas, Heemskerk, Johan W. M., Kuijpers, Marijke J. E., Stegner, David, Nieswandt, Bernhard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369317/ https://www.ncbi.nlm.nih.gov/pubmed/35955743 http://dx.doi.org/10.3390/ijms23158610 |
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