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Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function

Glycoprotein (GP) VI is the major platelet collagen receptor and a promising anti-thrombotic target. This was first demonstrated in mice using the rat monoclonal antibody JAQ1, which completely blocks the Collagen-Related Peptide (CRP)-binding site on mouse GPVI and efficiently inhibits mouse platel...

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Detalles Bibliográficos
Autores principales:	Navarro, Stefano, Starke, Andreas, Heemskerk, Johan W. M., Kuijpers, Marijke J. E., Stegner, David, Nieswandt, Bernhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369317/ https://www.ncbi.nlm.nih.gov/pubmed/35955743 http://dx.doi.org/10.3390/ijms23158610

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