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The Complement System, Aging, and Aging-Related Diseases

The complement system is a part of the immune system and consists of multiple complement components with biological functions such as defense against pathogens and immunomodulation. The complement system has three activation pathways: the classical pathway, the lectin pathway, and the alternative pa...

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Autores principales: Zheng, Runzi, Zhang, Yanghuan, Zhang, Ke, Yuan, Yang, Jia, Shuting, Liu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369321/
https://www.ncbi.nlm.nih.gov/pubmed/35955822
http://dx.doi.org/10.3390/ijms23158689
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author Zheng, Runzi
Zhang, Yanghuan
Zhang, Ke
Yuan, Yang
Jia, Shuting
Liu, Jing
author_facet Zheng, Runzi
Zhang, Yanghuan
Zhang, Ke
Yuan, Yang
Jia, Shuting
Liu, Jing
author_sort Zheng, Runzi
collection PubMed
description The complement system is a part of the immune system and consists of multiple complement components with biological functions such as defense against pathogens and immunomodulation. The complement system has three activation pathways: the classical pathway, the lectin pathway, and the alternative pathway. Increasing evidence indicates that the complement system plays a role in aging. Complement plays a role in inflammatory processes, metabolism, apoptosis, mitochondrial function, and Wnt signaling pathways. In addition, the complement system plays a significant role in aging-related diseases, including Alzheimer’s disease, age-related macular degeneration, and osteoarthritis. However, the effect of complement on aging and aging-related diseases is still unclear. Thus, a better understanding of the potential relationship between complement, aging, and aging-related diseases will provide molecular targets for treating aging, while focusing on the balance of complement in during treatment. Inhibition of a single component does not result in a good outcome. In this review, we discussed the research progress and effects of complement in aging and aging-related diseases.
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spelling pubmed-93693212022-08-12 The Complement System, Aging, and Aging-Related Diseases Zheng, Runzi Zhang, Yanghuan Zhang, Ke Yuan, Yang Jia, Shuting Liu, Jing Int J Mol Sci Review The complement system is a part of the immune system and consists of multiple complement components with biological functions such as defense against pathogens and immunomodulation. The complement system has three activation pathways: the classical pathway, the lectin pathway, and the alternative pathway. Increasing evidence indicates that the complement system plays a role in aging. Complement plays a role in inflammatory processes, metabolism, apoptosis, mitochondrial function, and Wnt signaling pathways. In addition, the complement system plays a significant role in aging-related diseases, including Alzheimer’s disease, age-related macular degeneration, and osteoarthritis. However, the effect of complement on aging and aging-related diseases is still unclear. Thus, a better understanding of the potential relationship between complement, aging, and aging-related diseases will provide molecular targets for treating aging, while focusing on the balance of complement in during treatment. Inhibition of a single component does not result in a good outcome. In this review, we discussed the research progress and effects of complement in aging and aging-related diseases. MDPI 2022-08-04 /pmc/articles/PMC9369321/ /pubmed/35955822 http://dx.doi.org/10.3390/ijms23158689 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zheng, Runzi
Zhang, Yanghuan
Zhang, Ke
Yuan, Yang
Jia, Shuting
Liu, Jing
The Complement System, Aging, and Aging-Related Diseases
title The Complement System, Aging, and Aging-Related Diseases
title_full The Complement System, Aging, and Aging-Related Diseases
title_fullStr The Complement System, Aging, and Aging-Related Diseases
title_full_unstemmed The Complement System, Aging, and Aging-Related Diseases
title_short The Complement System, Aging, and Aging-Related Diseases
title_sort complement system, aging, and aging-related diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369321/
https://www.ncbi.nlm.nih.gov/pubmed/35955822
http://dx.doi.org/10.3390/ijms23158689
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