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The Complement System, Aging, and Aging-Related Diseases
The complement system is a part of the immune system and consists of multiple complement components with biological functions such as defense against pathogens and immunomodulation. The complement system has three activation pathways: the classical pathway, the lectin pathway, and the alternative pa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369321/ https://www.ncbi.nlm.nih.gov/pubmed/35955822 http://dx.doi.org/10.3390/ijms23158689 |
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author | Zheng, Runzi Zhang, Yanghuan Zhang, Ke Yuan, Yang Jia, Shuting Liu, Jing |
author_facet | Zheng, Runzi Zhang, Yanghuan Zhang, Ke Yuan, Yang Jia, Shuting Liu, Jing |
author_sort | Zheng, Runzi |
collection | PubMed |
description | The complement system is a part of the immune system and consists of multiple complement components with biological functions such as defense against pathogens and immunomodulation. The complement system has three activation pathways: the classical pathway, the lectin pathway, and the alternative pathway. Increasing evidence indicates that the complement system plays a role in aging. Complement plays a role in inflammatory processes, metabolism, apoptosis, mitochondrial function, and Wnt signaling pathways. In addition, the complement system plays a significant role in aging-related diseases, including Alzheimer’s disease, age-related macular degeneration, and osteoarthritis. However, the effect of complement on aging and aging-related diseases is still unclear. Thus, a better understanding of the potential relationship between complement, aging, and aging-related diseases will provide molecular targets for treating aging, while focusing on the balance of complement in during treatment. Inhibition of a single component does not result in a good outcome. In this review, we discussed the research progress and effects of complement in aging and aging-related diseases. |
format | Online Article Text |
id | pubmed-9369321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93693212022-08-12 The Complement System, Aging, and Aging-Related Diseases Zheng, Runzi Zhang, Yanghuan Zhang, Ke Yuan, Yang Jia, Shuting Liu, Jing Int J Mol Sci Review The complement system is a part of the immune system and consists of multiple complement components with biological functions such as defense against pathogens and immunomodulation. The complement system has three activation pathways: the classical pathway, the lectin pathway, and the alternative pathway. Increasing evidence indicates that the complement system plays a role in aging. Complement plays a role in inflammatory processes, metabolism, apoptosis, mitochondrial function, and Wnt signaling pathways. In addition, the complement system plays a significant role in aging-related diseases, including Alzheimer’s disease, age-related macular degeneration, and osteoarthritis. However, the effect of complement on aging and aging-related diseases is still unclear. Thus, a better understanding of the potential relationship between complement, aging, and aging-related diseases will provide molecular targets for treating aging, while focusing on the balance of complement in during treatment. Inhibition of a single component does not result in a good outcome. In this review, we discussed the research progress and effects of complement in aging and aging-related diseases. MDPI 2022-08-04 /pmc/articles/PMC9369321/ /pubmed/35955822 http://dx.doi.org/10.3390/ijms23158689 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zheng, Runzi Zhang, Yanghuan Zhang, Ke Yuan, Yang Jia, Shuting Liu, Jing The Complement System, Aging, and Aging-Related Diseases |
title | The Complement System, Aging, and Aging-Related Diseases |
title_full | The Complement System, Aging, and Aging-Related Diseases |
title_fullStr | The Complement System, Aging, and Aging-Related Diseases |
title_full_unstemmed | The Complement System, Aging, and Aging-Related Diseases |
title_short | The Complement System, Aging, and Aging-Related Diseases |
title_sort | complement system, aging, and aging-related diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369321/ https://www.ncbi.nlm.nih.gov/pubmed/35955822 http://dx.doi.org/10.3390/ijms23158689 |
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