MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia

Dofetilide is a rapid delayed rectifier potassium current inhibitor widely used to prevent the recurrence of atrial fibrillation and flutter. The clinical use of this drug is associated with increases in QTc interval, which predispose patients to ventricular cardiac arrhythmias. The mechanisms invol...

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Detalles Bibliográficos
Autores principales: Uddin, Muhammad Erfan, Eisenmann, Eric D., Li, Yang, Huang, Kevin M., Garrison, Dominique A., Talebi, Zahra, Gibson, Alice A., Jin, Yan, Nepal, Mahesh, Bonilla, Ingrid M., Fu, Qiang, Sun, Xinxin, Millar, Alec, Tarasov, Mikhail, Jay, Christopher E., Cui, Xiaoming, Einolf, Heidi J., Pelis, Ryan M., Smith, Sakima A., Radwański, Przemysław B., Sweet, Douglas H., König, Jörg, Fromm, Martin F., Carnes, Cynthia A., Hu, Shuiying, Sparreboom, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369325/
https://www.ncbi.nlm.nih.gov/pubmed/35955741
http://dx.doi.org/10.3390/ijms23158607

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