Cargando…

Catheter-Associated Urinary Infections and Consequences of Using Coated versus Non-Coated Urethral Catheters—Outcomes of a Systematic Review and Meta-Analysis of Randomized Trials

Coated urethral catheters were introduced in clinical practice to reduce the risk of catheter-acquired urinary tract infection (CAUTI). We aimed to systematically review the incidence of CAUTI and adverse effects in randomized clinical trials of patients requiring indwelling bladder catheterization...

Descripción completa

Detalles Bibliográficos
Autores principales: Gauhar, Vineet, Castellani, Daniele, Teoh, Jeremy Yuen-Chun, Nedbal, Carlotta, Chiacchio, Giuseppe, Gabrielson, Andrew T., Heldwein, Flavio Lobo, Wroclawski, Marcelo Langer, de la Rosette, Jean, Donalisio da Silva, Rodrigo, Galosi, Andrea Benedetto, Somani, Bhaskar Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369369/
https://www.ncbi.nlm.nih.gov/pubmed/35956080
http://dx.doi.org/10.3390/jcm11154463
_version_ 1784766434446934016
author Gauhar, Vineet
Castellani, Daniele
Teoh, Jeremy Yuen-Chun
Nedbal, Carlotta
Chiacchio, Giuseppe
Gabrielson, Andrew T.
Heldwein, Flavio Lobo
Wroclawski, Marcelo Langer
de la Rosette, Jean
Donalisio da Silva, Rodrigo
Galosi, Andrea Benedetto
Somani, Bhaskar Kumar
author_facet Gauhar, Vineet
Castellani, Daniele
Teoh, Jeremy Yuen-Chun
Nedbal, Carlotta
Chiacchio, Giuseppe
Gabrielson, Andrew T.
Heldwein, Flavio Lobo
Wroclawski, Marcelo Langer
de la Rosette, Jean
Donalisio da Silva, Rodrigo
Galosi, Andrea Benedetto
Somani, Bhaskar Kumar
author_sort Gauhar, Vineet
collection PubMed
description Coated urethral catheters were introduced in clinical practice to reduce the risk of catheter-acquired urinary tract infection (CAUTI). We aimed to systematically review the incidence of CAUTI and adverse effects in randomized clinical trials of patients requiring indwelling bladder catheterization by comparing coated vs. non-coated catheters. This review was performed according to the 2020 PRISMA framework. The incidence of CAUTI and catheter-related adverse events was evaluated using the Cochran–Mantel–Haenszel method with a random-effects model and reported as the risk ratio (RR), 95% CI, and p-values. Significance was set at p < 0.05 and a 95% CI. Twelve studies including 36,783 patients were included for meta-analysis. There was no significant difference in the CAUTI rate between coated and non-coated catheters (RR 0.87 95% CI 0.75–1.00, p = 0.06). Subgroup analysis demonstrated that the risk of CAUTI was significantly lower in the coated group compared with the non-coated group among patients requiring long-term catheterization (>14 days) (RR 0.82 95% CI 0.68–0.99, p = 0.04). There was no difference between the two groups in the incidence of the need for catheter exchange or the incidence of lower urinary tract symptoms after catheter removal. The benefit of coated catheters in reducing CAUTI risk among patients requiring long-term catheterization should be balanced against the increased direct costs to health care systems when compared to non-coated catheters.
format Online
Article
Text
id pubmed-9369369
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93693692022-08-12 Catheter-Associated Urinary Infections and Consequences of Using Coated versus Non-Coated Urethral Catheters—Outcomes of a Systematic Review and Meta-Analysis of Randomized Trials Gauhar, Vineet Castellani, Daniele Teoh, Jeremy Yuen-Chun Nedbal, Carlotta Chiacchio, Giuseppe Gabrielson, Andrew T. Heldwein, Flavio Lobo Wroclawski, Marcelo Langer de la Rosette, Jean Donalisio da Silva, Rodrigo Galosi, Andrea Benedetto Somani, Bhaskar Kumar J Clin Med Review Coated urethral catheters were introduced in clinical practice to reduce the risk of catheter-acquired urinary tract infection (CAUTI). We aimed to systematically review the incidence of CAUTI and adverse effects in randomized clinical trials of patients requiring indwelling bladder catheterization by comparing coated vs. non-coated catheters. This review was performed according to the 2020 PRISMA framework. The incidence of CAUTI and catheter-related adverse events was evaluated using the Cochran–Mantel–Haenszel method with a random-effects model and reported as the risk ratio (RR), 95% CI, and p-values. Significance was set at p < 0.05 and a 95% CI. Twelve studies including 36,783 patients were included for meta-analysis. There was no significant difference in the CAUTI rate between coated and non-coated catheters (RR 0.87 95% CI 0.75–1.00, p = 0.06). Subgroup analysis demonstrated that the risk of CAUTI was significantly lower in the coated group compared with the non-coated group among patients requiring long-term catheterization (>14 days) (RR 0.82 95% CI 0.68–0.99, p = 0.04). There was no difference between the two groups in the incidence of the need for catheter exchange or the incidence of lower urinary tract symptoms after catheter removal. The benefit of coated catheters in reducing CAUTI risk among patients requiring long-term catheterization should be balanced against the increased direct costs to health care systems when compared to non-coated catheters. MDPI 2022-07-30 /pmc/articles/PMC9369369/ /pubmed/35956080 http://dx.doi.org/10.3390/jcm11154463 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gauhar, Vineet
Castellani, Daniele
Teoh, Jeremy Yuen-Chun
Nedbal, Carlotta
Chiacchio, Giuseppe
Gabrielson, Andrew T.
Heldwein, Flavio Lobo
Wroclawski, Marcelo Langer
de la Rosette, Jean
Donalisio da Silva, Rodrigo
Galosi, Andrea Benedetto
Somani, Bhaskar Kumar
Catheter-Associated Urinary Infections and Consequences of Using Coated versus Non-Coated Urethral Catheters—Outcomes of a Systematic Review and Meta-Analysis of Randomized Trials
title Catheter-Associated Urinary Infections and Consequences of Using Coated versus Non-Coated Urethral Catheters—Outcomes of a Systematic Review and Meta-Analysis of Randomized Trials
title_full Catheter-Associated Urinary Infections and Consequences of Using Coated versus Non-Coated Urethral Catheters—Outcomes of a Systematic Review and Meta-Analysis of Randomized Trials
title_fullStr Catheter-Associated Urinary Infections and Consequences of Using Coated versus Non-Coated Urethral Catheters—Outcomes of a Systematic Review and Meta-Analysis of Randomized Trials
title_full_unstemmed Catheter-Associated Urinary Infections and Consequences of Using Coated versus Non-Coated Urethral Catheters—Outcomes of a Systematic Review and Meta-Analysis of Randomized Trials
title_short Catheter-Associated Urinary Infections and Consequences of Using Coated versus Non-Coated Urethral Catheters—Outcomes of a Systematic Review and Meta-Analysis of Randomized Trials
title_sort catheter-associated urinary infections and consequences of using coated versus non-coated urethral catheters—outcomes of a systematic review and meta-analysis of randomized trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369369/
https://www.ncbi.nlm.nih.gov/pubmed/35956080
http://dx.doi.org/10.3390/jcm11154463
work_keys_str_mv AT gauharvineet catheterassociatedurinaryinfectionsandconsequencesofusingcoatedversusnoncoatedurethralcathetersoutcomesofasystematicreviewandmetaanalysisofrandomizedtrials
AT castellanidaniele catheterassociatedurinaryinfectionsandconsequencesofusingcoatedversusnoncoatedurethralcathetersoutcomesofasystematicreviewandmetaanalysisofrandomizedtrials
AT teohjeremyyuenchun catheterassociatedurinaryinfectionsandconsequencesofusingcoatedversusnoncoatedurethralcathetersoutcomesofasystematicreviewandmetaanalysisofrandomizedtrials
AT nedbalcarlotta catheterassociatedurinaryinfectionsandconsequencesofusingcoatedversusnoncoatedurethralcathetersoutcomesofasystematicreviewandmetaanalysisofrandomizedtrials
AT chiacchiogiuseppe catheterassociatedurinaryinfectionsandconsequencesofusingcoatedversusnoncoatedurethralcathetersoutcomesofasystematicreviewandmetaanalysisofrandomizedtrials
AT gabrielsonandrewt catheterassociatedurinaryinfectionsandconsequencesofusingcoatedversusnoncoatedurethralcathetersoutcomesofasystematicreviewandmetaanalysisofrandomizedtrials
AT heldweinflaviolobo catheterassociatedurinaryinfectionsandconsequencesofusingcoatedversusnoncoatedurethralcathetersoutcomesofasystematicreviewandmetaanalysisofrandomizedtrials
AT wroclawskimarcelolanger catheterassociatedurinaryinfectionsandconsequencesofusingcoatedversusnoncoatedurethralcathetersoutcomesofasystematicreviewandmetaanalysisofrandomizedtrials
AT delarosettejean catheterassociatedurinaryinfectionsandconsequencesofusingcoatedversusnoncoatedurethralcathetersoutcomesofasystematicreviewandmetaanalysisofrandomizedtrials
AT donalisiodasilvarodrigo catheterassociatedurinaryinfectionsandconsequencesofusingcoatedversusnoncoatedurethralcathetersoutcomesofasystematicreviewandmetaanalysisofrandomizedtrials
AT galosiandreabenedetto catheterassociatedurinaryinfectionsandconsequencesofusingcoatedversusnoncoatedurethralcathetersoutcomesofasystematicreviewandmetaanalysisofrandomizedtrials
AT somanibhaskarkumar catheterassociatedurinaryinfectionsandconsequencesofusingcoatedversusnoncoatedurethralcathetersoutcomesofasystematicreviewandmetaanalysisofrandomizedtrials