Correction of Fanconi Anemia Mutations Using Digital Genome Engineering

Fanconi anemia (FA) is a rare genetic disease in which genes essential for DNA repair are mutated. Both the interstrand crosslink (ICL) and double-strand break (DSB) repair pathways are disrupted in FA, leading to patient bone marrow failure (BMF) and cancer predisposition. The only curative therapy...

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Detalles Bibliográficos
Autores principales: Sipe, Christopher J., Kluesner, Mitchell G., Bingea, Samuel P., Lahr, Walker S., Andrew, Aneesha A., Wang, Minjing, DeFeo, Anthony P., Hinkel, Timothy L., Laoharawee, Kanut, Wagner, John E., MacMillan, Margaret L., Vercellotti, Gregory M., Tolar, Jakub, Osborn, Mark J., McIvor, R. Scott, Webber, Beau R., Moriarity, Branden S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369391/
https://www.ncbi.nlm.nih.gov/pubmed/35955545
http://dx.doi.org/10.3390/ijms23158416

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