Aberrant Splicing of INS Impairs Beta-Cell Differentiation and Proliferation by ER Stress in the Isogenic iPSC Model of Neonatal Diabetes

One of the causes of diabetes in infants is the defect of the insulin gene (INS). Gene mutations can lead to proinsulin misfolding, an increased endoplasmic reticulum (ER) stress and possible beta-cell apoptosis. In humans, the mechanisms underlying beta-cell failure remain unclear. We generated ind...

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Detalles Bibliográficos
Autores principales: Panova, Alexandra V., Klementieva, Natalia V., Sycheva, Anna V., Korobko, Elena V., Sosnovtseva, Anastasia O., Krasnova, Tatiana S., Karpova, Maria R., Rubtsov, Petr M., Tikhonovich, Yulia V., Tiulpakov, Anatoly N., Kiselev, Sergey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369396/
https://www.ncbi.nlm.nih.gov/pubmed/35955956
http://dx.doi.org/10.3390/ijms23158824

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