Four Cholesterol-Recognition Motifs in the Pore-Forming and Translocation Domains of Adenylate Cyclase Toxin Are Essential for Invasion of Eukaryotic Cells and Lysis of Erythrocytes

Adenylate Cyclase Toxin (ACT or CyaA) is one of the important virulence factors secreted by Bordetella pertussis, the bacterium causative of whooping cough. ACT debilitates host defenses by production of unregulated levels of cAMP into the cell cytosol upon delivery of its N-terminal domain with ade...

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Detalles Bibliográficos
Autores principales: Amuategi, Jone, Alonso, Rocío, Ostolaza, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369406/
https://www.ncbi.nlm.nih.gov/pubmed/35955837
http://dx.doi.org/10.3390/ijms23158703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369406/
https://www.ncbi.nlm.nih.gov/pubmed/35955837
http://dx.doi.org/10.3390/ijms23158703

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