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Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review
Wound dressing design is a dynamic and rapidly growing field of the medical wound-care market worldwide. Advances in technology have resulted in the development of a wide range of wound dressings that treat different types of wounds by targeting the four phases of healing. The ideal wound dressing s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369430/ https://www.ncbi.nlm.nih.gov/pubmed/35955912 http://dx.doi.org/10.3390/ijms23158778 |
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author | Gardikiotis, Ioannis Cojocaru, Florina-Daniela Mihai, Cosmin-Teodor Balan, Vera Dodi, Gianina |
author_facet | Gardikiotis, Ioannis Cojocaru, Florina-Daniela Mihai, Cosmin-Teodor Balan, Vera Dodi, Gianina |
author_sort | Gardikiotis, Ioannis |
collection | PubMed |
description | Wound dressing design is a dynamic and rapidly growing field of the medical wound-care market worldwide. Advances in technology have resulted in the development of a wide range of wound dressings that treat different types of wounds by targeting the four phases of healing. The ideal wound dressing should perform rapid healing; preserve the body’s water content; be oxygen permeable, non-adherent on the wound and hypoallergenic; and provide a barrier against external contaminants—at a reasonable cost and with minimal inconvenience to the patient. Therefore, choosing the best dressing should be based on what the wound needs and what the dressing does to achieve complete regeneration and restoration of the skin’s structure and function. Biopolymers, such as alginate (ALG), chitosan (Cs), collagen (Col), hyaluronic acid (HA) and silk fibroin (SF), are extensively used in wound management due to their biocompatibility, biodegradability and similarity to macromolecules recognized by the human body. However, most of the formulations based on biopolymers still show various issues; thus, strategies to combine them with molecular biology approaches represent the future of wound healing. Therefore, this article provides an overview of biopolymers’ roles in wound physiology as a perspective on the development of a new generation of enhanced, naturally inspired, smart wound dressings based on blood products, stem cells and growth factors. |
format | Online Article Text |
id | pubmed-9369430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93694302022-08-12 Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review Gardikiotis, Ioannis Cojocaru, Florina-Daniela Mihai, Cosmin-Teodor Balan, Vera Dodi, Gianina Int J Mol Sci Review Wound dressing design is a dynamic and rapidly growing field of the medical wound-care market worldwide. Advances in technology have resulted in the development of a wide range of wound dressings that treat different types of wounds by targeting the four phases of healing. The ideal wound dressing should perform rapid healing; preserve the body’s water content; be oxygen permeable, non-adherent on the wound and hypoallergenic; and provide a barrier against external contaminants—at a reasonable cost and with minimal inconvenience to the patient. Therefore, choosing the best dressing should be based on what the wound needs and what the dressing does to achieve complete regeneration and restoration of the skin’s structure and function. Biopolymers, such as alginate (ALG), chitosan (Cs), collagen (Col), hyaluronic acid (HA) and silk fibroin (SF), are extensively used in wound management due to their biocompatibility, biodegradability and similarity to macromolecules recognized by the human body. However, most of the formulations based on biopolymers still show various issues; thus, strategies to combine them with molecular biology approaches represent the future of wound healing. Therefore, this article provides an overview of biopolymers’ roles in wound physiology as a perspective on the development of a new generation of enhanced, naturally inspired, smart wound dressings based on blood products, stem cells and growth factors. MDPI 2022-08-07 /pmc/articles/PMC9369430/ /pubmed/35955912 http://dx.doi.org/10.3390/ijms23158778 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gardikiotis, Ioannis Cojocaru, Florina-Daniela Mihai, Cosmin-Teodor Balan, Vera Dodi, Gianina Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review |
title | Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review |
title_full | Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review |
title_fullStr | Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review |
title_full_unstemmed | Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review |
title_short | Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review |
title_sort | borrowing the features of biopolymers for emerging wound healing dressings: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369430/ https://www.ncbi.nlm.nih.gov/pubmed/35955912 http://dx.doi.org/10.3390/ijms23158778 |
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