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Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study

Introduction: We explored the association between clinical outcomes and the cleavage rate of day-3 cleavage slow-growing embryos after overnight culture. Methods: The data collected from 303 frozen embryo transfer (FET) cycles with 606 4-cell or 5-cell embryos cultured overnight (18–22 h) after thaw...

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Autores principales: Geng, Lan, Lin, Xinran, Liu, Rang, Wu, Jiahui, Luo, Yongsheng, Sun, Hongmei, Hou, Zhenhui, Zhang, Qiuju, Xu, Chang, Li, Xiao, Cao, Canhui, Wang, Tianren, Xia, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369477/
https://www.ncbi.nlm.nih.gov/pubmed/35956032
http://dx.doi.org/10.3390/jcm11154417
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author Geng, Lan
Lin, Xinran
Liu, Rang
Wu, Jiahui
Luo, Yongsheng
Sun, Hongmei
Hou, Zhenhui
Zhang, Qiuju
Xu, Chang
Li, Xiao
Cao, Canhui
Wang, Tianren
Xia, Xi
author_facet Geng, Lan
Lin, Xinran
Liu, Rang
Wu, Jiahui
Luo, Yongsheng
Sun, Hongmei
Hou, Zhenhui
Zhang, Qiuju
Xu, Chang
Li, Xiao
Cao, Canhui
Wang, Tianren
Xia, Xi
author_sort Geng, Lan
collection PubMed
description Introduction: We explored the association between clinical outcomes and the cleavage rate of day-3 cleavage slow-growing embryos after overnight culture. Methods: The data collected from 303 frozen embryo transfer (FET) cycles with 606 4-cell or 5-cell embryos cultured overnight (18–22 h) after thawing were analyzed. Based on the growth rate after the overnight culture, the embryos were divided into three groups: no embryo reaching eight cells (Group I), either one of the two embryos reaching eight cells (Group II), and both two embryos reaching eight cells or more (Group III). A statistical analysis of the different clinical outcomes from the three groups was performed. Results: Biochemical pregnancy rate (OR 3.22; p = 0.001), implantation rate (OR 2.44; p = 0.002), clinical pregnancy rate (OR 3.04; p = 0.001), ongoing pregnancy rate (OR 3.14; p = 0.001), and live birth rate (OR 2.78; p = 0.004) were significantly higher in Group III as compared to Group I. Group II had a significantly higher biochemical pregnancy rate (OR 2.02; p = 0.013) and implantation rate (OR 1.77; p = 0.019) than Group I. Conclusions: The capability of day-3 cleavage slow-growing embryos to reach eight cells, especially that of two embryos reaching eight cells by overnight culture, appear to result in a better pregnancy outcome.
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spelling pubmed-93694772022-08-12 Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study Geng, Lan Lin, Xinran Liu, Rang Wu, Jiahui Luo, Yongsheng Sun, Hongmei Hou, Zhenhui Zhang, Qiuju Xu, Chang Li, Xiao Cao, Canhui Wang, Tianren Xia, Xi J Clin Med Article Introduction: We explored the association between clinical outcomes and the cleavage rate of day-3 cleavage slow-growing embryos after overnight culture. Methods: The data collected from 303 frozen embryo transfer (FET) cycles with 606 4-cell or 5-cell embryos cultured overnight (18–22 h) after thawing were analyzed. Based on the growth rate after the overnight culture, the embryos were divided into three groups: no embryo reaching eight cells (Group I), either one of the two embryos reaching eight cells (Group II), and both two embryos reaching eight cells or more (Group III). A statistical analysis of the different clinical outcomes from the three groups was performed. Results: Biochemical pregnancy rate (OR 3.22; p = 0.001), implantation rate (OR 2.44; p = 0.002), clinical pregnancy rate (OR 3.04; p = 0.001), ongoing pregnancy rate (OR 3.14; p = 0.001), and live birth rate (OR 2.78; p = 0.004) were significantly higher in Group III as compared to Group I. Group II had a significantly higher biochemical pregnancy rate (OR 2.02; p = 0.013) and implantation rate (OR 1.77; p = 0.019) than Group I. Conclusions: The capability of day-3 cleavage slow-growing embryos to reach eight cells, especially that of two embryos reaching eight cells by overnight culture, appear to result in a better pregnancy outcome. MDPI 2022-07-29 /pmc/articles/PMC9369477/ /pubmed/35956032 http://dx.doi.org/10.3390/jcm11154417 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Geng, Lan
Lin, Xinran
Liu, Rang
Wu, Jiahui
Luo, Yongsheng
Sun, Hongmei
Hou, Zhenhui
Zhang, Qiuju
Xu, Chang
Li, Xiao
Cao, Canhui
Wang, Tianren
Xia, Xi
Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study
title Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study
title_full Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study
title_fullStr Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study
title_full_unstemmed Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study
title_short Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study
title_sort clinical outcome of day-3 cleavage slow-growing embryos at different cleavage rates after overnight culture: a cohort retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369477/
https://www.ncbi.nlm.nih.gov/pubmed/35956032
http://dx.doi.org/10.3390/jcm11154417
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