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PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment

Recent literature has stressed the importance of vitamin D (VD) in polycystic ovary syndrome (PCOS). Women with PCOS are deficient in VD, particularly those with a higher weight. Hypovitaminosis is a risk factor for glucose intolerance, and reduced levels of VD is associated with insulin resistance...

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Autores principales: Morgante, Giuseppe, Darino, Ilenia, Spanò, Amelia, Luisi, Stefano, Luddi, Alice, Piomboni, Paola, Governini, Laura, De Leo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369478/
https://www.ncbi.nlm.nih.gov/pubmed/35956124
http://dx.doi.org/10.3390/jcm11154509
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author Morgante, Giuseppe
Darino, Ilenia
Spanò, Amelia
Luisi, Stefano
Luddi, Alice
Piomboni, Paola
Governini, Laura
De Leo, Vincenzo
author_facet Morgante, Giuseppe
Darino, Ilenia
Spanò, Amelia
Luisi, Stefano
Luddi, Alice
Piomboni, Paola
Governini, Laura
De Leo, Vincenzo
author_sort Morgante, Giuseppe
collection PubMed
description Recent literature has stressed the importance of vitamin D (VD) in polycystic ovary syndrome (PCOS). Women with PCOS are deficient in VD, particularly those with a higher weight. Hypovitaminosis is a risk factor for glucose intolerance, and reduced levels of VD is associated with insulin resistance and increased diabetes risk. Since women with PCOS and hirsutism seem to have lower levels of VD than women with PCOS without hirsutism, a correlation between VD deficiency and hyperandrogenism may be suggested. Interestingly, VD is crucial for many human physiological functions, including to counteract inflammation and oxidative stress. Some studies evaluated effects of VD supplementation on glucose homeostasis variables, hormonal status, lipid concentrations, and biomarkers of inflammation and oxidative stress among VD-deficient women. Moreover, VD has been shown to play a role in egg quality and fertility. This review aims to show the relationship between VD and the endocrine and metabolic profile of PCOS patients, as well as its implications for their fertility. The supplement of VD to the common therapy can lead to an improvement of the insulin resistance and lipid metabolism, a reduction of circulating androgens, as well as a better response to the induction of ovulation in PCOS women.
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spelling pubmed-93694782022-08-12 PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment Morgante, Giuseppe Darino, Ilenia Spanò, Amelia Luisi, Stefano Luddi, Alice Piomboni, Paola Governini, Laura De Leo, Vincenzo J Clin Med Review Recent literature has stressed the importance of vitamin D (VD) in polycystic ovary syndrome (PCOS). Women with PCOS are deficient in VD, particularly those with a higher weight. Hypovitaminosis is a risk factor for glucose intolerance, and reduced levels of VD is associated with insulin resistance and increased diabetes risk. Since women with PCOS and hirsutism seem to have lower levels of VD than women with PCOS without hirsutism, a correlation between VD deficiency and hyperandrogenism may be suggested. Interestingly, VD is crucial for many human physiological functions, including to counteract inflammation and oxidative stress. Some studies evaluated effects of VD supplementation on glucose homeostasis variables, hormonal status, lipid concentrations, and biomarkers of inflammation and oxidative stress among VD-deficient women. Moreover, VD has been shown to play a role in egg quality and fertility. This review aims to show the relationship between VD and the endocrine and metabolic profile of PCOS patients, as well as its implications for their fertility. The supplement of VD to the common therapy can lead to an improvement of the insulin resistance and lipid metabolism, a reduction of circulating androgens, as well as a better response to the induction of ovulation in PCOS women. MDPI 2022-08-02 /pmc/articles/PMC9369478/ /pubmed/35956124 http://dx.doi.org/10.3390/jcm11154509 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Morgante, Giuseppe
Darino, Ilenia
Spanò, Amelia
Luisi, Stefano
Luddi, Alice
Piomboni, Paola
Governini, Laura
De Leo, Vincenzo
PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment
title PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment
title_full PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment
title_fullStr PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment
title_full_unstemmed PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment
title_short PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment
title_sort pcos physiopathology and vitamin d deficiency: biological insights and perspectives for treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369478/
https://www.ncbi.nlm.nih.gov/pubmed/35956124
http://dx.doi.org/10.3390/jcm11154509
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