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The Anemia Stress Index—Anemia, Transfusions, and Mortality in Patients with Continuous Flow Ventricular Assist Devices
We aimed to identify a simple metric accounting for peri-procedural hemoglobin changes, independent of blood product transfusion strategies, and assess its correlation with outcomes in patients undergoing left ventricular assist device (LVAD) implantation We included consecutive patients undergoing...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369576/ https://www.ncbi.nlm.nih.gov/pubmed/35956132 http://dx.doi.org/10.3390/jcm11154517 |
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author | Shore, Supriya Hanff, Thomas C. Mazurek, Jeremy A. Fox, Arieh Tanna, Monique S. Grandin, Edward W. Zhang, Robert Wald, Joyce Peters, Carli Acker, Michael A. Atluri, Pavan Rame, J. Eduardo Goldberg, Lee R. Jessup, Mariell Margulies, Kenneth B. Birati, Edo Y. |
author_facet | Shore, Supriya Hanff, Thomas C. Mazurek, Jeremy A. Fox, Arieh Tanna, Monique S. Grandin, Edward W. Zhang, Robert Wald, Joyce Peters, Carli Acker, Michael A. Atluri, Pavan Rame, J. Eduardo Goldberg, Lee R. Jessup, Mariell Margulies, Kenneth B. Birati, Edo Y. |
author_sort | Shore, Supriya |
collection | PubMed |
description | We aimed to identify a simple metric accounting for peri-procedural hemoglobin changes, independent of blood product transfusion strategies, and assess its correlation with outcomes in patients undergoing left ventricular assist device (LVAD) implantation We included consecutive patients undergoing LVAD implantation at a single center between 10/1/2008 and 6/1/2014. The anemia stress index (ASI), defined as the sum of number of packed red blood cells transfused and the hemoglobin changes after LVAD implantation, was calculated for each patient at 24 h, discharge, and 3 months after LVAD implantation. Our cohort included 166 patients (80.1% males, mean age 56.3 ± 15.6 years) followed up for a median of 12.3 months. Increases in ASI per unit were associated with a higher hazard for all-cause mortality and early RV failure. The associations between the ASI and all-cause mortality persisted after multivariable adjustment, irrespective of when it was calculated (adjusted HR of 1.11, 95% CI 1.03–1.20 per unit increase in ASI). Similarly, ASI at 24 h after implant was associated with early RV failure despite multivariable adjustment (OR 1.09, 95% CI 1.05–1.14). We present a novel metric, the ASI, that is correlated with an increased risk for all-cause mortality and early RV failure in LVAD recipients. |
format | Online Article Text |
id | pubmed-9369576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93695762022-08-12 The Anemia Stress Index—Anemia, Transfusions, and Mortality in Patients with Continuous Flow Ventricular Assist Devices Shore, Supriya Hanff, Thomas C. Mazurek, Jeremy A. Fox, Arieh Tanna, Monique S. Grandin, Edward W. Zhang, Robert Wald, Joyce Peters, Carli Acker, Michael A. Atluri, Pavan Rame, J. Eduardo Goldberg, Lee R. Jessup, Mariell Margulies, Kenneth B. Birati, Edo Y. J Clin Med Article We aimed to identify a simple metric accounting for peri-procedural hemoglobin changes, independent of blood product transfusion strategies, and assess its correlation with outcomes in patients undergoing left ventricular assist device (LVAD) implantation We included consecutive patients undergoing LVAD implantation at a single center between 10/1/2008 and 6/1/2014. The anemia stress index (ASI), defined as the sum of number of packed red blood cells transfused and the hemoglobin changes after LVAD implantation, was calculated for each patient at 24 h, discharge, and 3 months after LVAD implantation. Our cohort included 166 patients (80.1% males, mean age 56.3 ± 15.6 years) followed up for a median of 12.3 months. Increases in ASI per unit were associated with a higher hazard for all-cause mortality and early RV failure. The associations between the ASI and all-cause mortality persisted after multivariable adjustment, irrespective of when it was calculated (adjusted HR of 1.11, 95% CI 1.03–1.20 per unit increase in ASI). Similarly, ASI at 24 h after implant was associated with early RV failure despite multivariable adjustment (OR 1.09, 95% CI 1.05–1.14). We present a novel metric, the ASI, that is correlated with an increased risk for all-cause mortality and early RV failure in LVAD recipients. MDPI 2022-08-03 /pmc/articles/PMC9369576/ /pubmed/35956132 http://dx.doi.org/10.3390/jcm11154517 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shore, Supriya Hanff, Thomas C. Mazurek, Jeremy A. Fox, Arieh Tanna, Monique S. Grandin, Edward W. Zhang, Robert Wald, Joyce Peters, Carli Acker, Michael A. Atluri, Pavan Rame, J. Eduardo Goldberg, Lee R. Jessup, Mariell Margulies, Kenneth B. Birati, Edo Y. The Anemia Stress Index—Anemia, Transfusions, and Mortality in Patients with Continuous Flow Ventricular Assist Devices |
title | The Anemia Stress Index—Anemia, Transfusions, and Mortality in Patients with Continuous Flow Ventricular Assist Devices |
title_full | The Anemia Stress Index—Anemia, Transfusions, and Mortality in Patients with Continuous Flow Ventricular Assist Devices |
title_fullStr | The Anemia Stress Index—Anemia, Transfusions, and Mortality in Patients with Continuous Flow Ventricular Assist Devices |
title_full_unstemmed | The Anemia Stress Index—Anemia, Transfusions, and Mortality in Patients with Continuous Flow Ventricular Assist Devices |
title_short | The Anemia Stress Index—Anemia, Transfusions, and Mortality in Patients with Continuous Flow Ventricular Assist Devices |
title_sort | anemia stress index—anemia, transfusions, and mortality in patients with continuous flow ventricular assist devices |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369576/ https://www.ncbi.nlm.nih.gov/pubmed/35956132 http://dx.doi.org/10.3390/jcm11154517 |
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