Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis

Five new triterpenoids, oenotheralanosterols C-G (1–5), with seven known triterpenoidcompounds, namely 2α,3α,19α-trihydroxy-24-norurs4,12-dien-28-oic acid (6), 3β,23-dihydroxy-1-oxo-olean-12-en-28-oic acid (7), remangilone C (8), knoxivalic acid A (9), termichebulolide (10), rosasecotriterpene A (11...

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Autores principales: Liu, Juanjuan, Zhang, Jingke, Zeng, Mengnan, Li, Meng, Xie, Shuangshuang, Zheng, Xiaoke, Feng, Weisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369581/
https://www.ncbi.nlm.nih.gov/pubmed/35956820
http://dx.doi.org/10.3390/molecules27154870
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author Liu, Juanjuan
Zhang, Jingke
Zeng, Mengnan
Li, Meng
Xie, Shuangshuang
Zheng, Xiaoke
Feng, Weisheng
author_facet Liu, Juanjuan
Zhang, Jingke
Zeng, Mengnan
Li, Meng
Xie, Shuangshuang
Zheng, Xiaoke
Feng, Weisheng
author_sort Liu, Juanjuan
collection PubMed
description Five new triterpenoids, oenotheralanosterols C-G (1–5), with seven known triterpenoidcompounds, namely 2α,3α,19α-trihydroxy-24-norurs4,12-dien-28-oic acid (6), 3β,23-dihydroxy-1-oxo-olean-12-en-28-oic acid (7), remangilone C (8), knoxivalic acid A (9), termichebulolide (10), rosasecotriterpene A (11), androsanortriterpene C (12), were extracted and separated from the dichloromethane part of Oenothera biennis L. The anti-pulmonary fibrosis activities of all the compounds against TGF-β1-induced damage tonormal human lung epithelial (BEAS-2B) cells were investigated in vitro. The results showed that compounds 1–2, 6, 8, and 11 exhibited significant anti-pulmonary fibrosis activities, with EC(50) values ranging from 4.7 μM to 9.9 μM.
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spelling pubmed-93695812022-08-12 Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis Liu, Juanjuan Zhang, Jingke Zeng, Mengnan Li, Meng Xie, Shuangshuang Zheng, Xiaoke Feng, Weisheng Molecules Article Five new triterpenoids, oenotheralanosterols C-G (1–5), with seven known triterpenoidcompounds, namely 2α,3α,19α-trihydroxy-24-norurs4,12-dien-28-oic acid (6), 3β,23-dihydroxy-1-oxo-olean-12-en-28-oic acid (7), remangilone C (8), knoxivalic acid A (9), termichebulolide (10), rosasecotriterpene A (11), androsanortriterpene C (12), were extracted and separated from the dichloromethane part of Oenothera biennis L. The anti-pulmonary fibrosis activities of all the compounds against TGF-β1-induced damage tonormal human lung epithelial (BEAS-2B) cells were investigated in vitro. The results showed that compounds 1–2, 6, 8, and 11 exhibited significant anti-pulmonary fibrosis activities, with EC(50) values ranging from 4.7 μM to 9.9 μM. MDPI 2022-07-29 /pmc/articles/PMC9369581/ /pubmed/35956820 http://dx.doi.org/10.3390/molecules27154870 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Juanjuan
Zhang, Jingke
Zeng, Mengnan
Li, Meng
Xie, Shuangshuang
Zheng, Xiaoke
Feng, Weisheng
Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis
title Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis
title_full Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis
title_fullStr Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis
title_full_unstemmed Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis
title_short Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis
title_sort anti-pulmonary fibrosis activities of triterpenoids from oenothera biennis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369581/
https://www.ncbi.nlm.nih.gov/pubmed/35956820
http://dx.doi.org/10.3390/molecules27154870
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