Cargando…
New Oral Antitumor Drugs and Medication Safety in Uro-Oncology: Implications for Clinical Practice Based on a Subgroup Analysis of the AMBORA Trial
Oral antitumor therapeutics (OAT) bear a high risk for medication errors, e.g., due to drug–drug or drug–food interactions or incorrect drug intake. Advanced age, organ insufficiencies, and polymedication are putting uro-oncological patients at an even larger risk. This analysis sets out to (1) inve...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369799/ https://www.ncbi.nlm.nih.gov/pubmed/35956173 http://dx.doi.org/10.3390/jcm11154558 |
_version_ | 1784766583697047552 |
---|---|
author | Schlichtig, Katja Cuba, Lisa Dürr, Pauline Bellut, Laura Meidenbauer, Norbert Kunath, Frank Goebell, Peter J. Mackensen, Andreas Dörje, Frank Fromm, Martin F. Wullich, Bernd |
author_facet | Schlichtig, Katja Cuba, Lisa Dürr, Pauline Bellut, Laura Meidenbauer, Norbert Kunath, Frank Goebell, Peter J. Mackensen, Andreas Dörje, Frank Fromm, Martin F. Wullich, Bernd |
author_sort | Schlichtig, Katja |
collection | PubMed |
description | Oral antitumor therapeutics (OAT) bear a high risk for medication errors, e.g., due to drug–drug or drug–food interactions or incorrect drug intake. Advanced age, organ insufficiencies, and polymedication are putting uro-oncological patients at an even larger risk. This analysis sets out to (1) investigate the frequency and relevance of medication errors in patients with prostate cancer or renal cell carcinoma treated with OAT and (2) compile recommendations for clinical practice. This post-hoc subgroup analysis used data collected in the randomized AMBORA trial (2017–2020; DRKS00013271). Clinical pharmacologists/pharmacists conducted advanced medication reviews over 12 weeks after initiation of a new oral regimen and assessed the complete medication process for drug–related problems. Medication errors related to either the OAT, prescribed or prescription-free concomitant medication, or food were classified regarding cause and severity. We identified 67 medication errors in 38 patients within the complete medication within 12 weeks. Thereof, 55% were detected at therapy initiation, 27% were caused by the patients, and 25% were drug–drug or drug–food interactions. Problem-prone issues are summarized in a ‘medication safety table’ to provide recommendations for clinical practice in uro-oncology. Tailored strategies including intensified care by clinical pharmacologists/pharmacists should be implemented in clinical practice to improve medication safety. |
format | Online Article Text |
id | pubmed-9369799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93697992022-08-12 New Oral Antitumor Drugs and Medication Safety in Uro-Oncology: Implications for Clinical Practice Based on a Subgroup Analysis of the AMBORA Trial Schlichtig, Katja Cuba, Lisa Dürr, Pauline Bellut, Laura Meidenbauer, Norbert Kunath, Frank Goebell, Peter J. Mackensen, Andreas Dörje, Frank Fromm, Martin F. Wullich, Bernd J Clin Med Article Oral antitumor therapeutics (OAT) bear a high risk for medication errors, e.g., due to drug–drug or drug–food interactions or incorrect drug intake. Advanced age, organ insufficiencies, and polymedication are putting uro-oncological patients at an even larger risk. This analysis sets out to (1) investigate the frequency and relevance of medication errors in patients with prostate cancer or renal cell carcinoma treated with OAT and (2) compile recommendations for clinical practice. This post-hoc subgroup analysis used data collected in the randomized AMBORA trial (2017–2020; DRKS00013271). Clinical pharmacologists/pharmacists conducted advanced medication reviews over 12 weeks after initiation of a new oral regimen and assessed the complete medication process for drug–related problems. Medication errors related to either the OAT, prescribed or prescription-free concomitant medication, or food were classified regarding cause and severity. We identified 67 medication errors in 38 patients within the complete medication within 12 weeks. Thereof, 55% were detected at therapy initiation, 27% were caused by the patients, and 25% were drug–drug or drug–food interactions. Problem-prone issues are summarized in a ‘medication safety table’ to provide recommendations for clinical practice in uro-oncology. Tailored strategies including intensified care by clinical pharmacologists/pharmacists should be implemented in clinical practice to improve medication safety. MDPI 2022-08-04 /pmc/articles/PMC9369799/ /pubmed/35956173 http://dx.doi.org/10.3390/jcm11154558 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schlichtig, Katja Cuba, Lisa Dürr, Pauline Bellut, Laura Meidenbauer, Norbert Kunath, Frank Goebell, Peter J. Mackensen, Andreas Dörje, Frank Fromm, Martin F. Wullich, Bernd New Oral Antitumor Drugs and Medication Safety in Uro-Oncology: Implications for Clinical Practice Based on a Subgroup Analysis of the AMBORA Trial |
title | New Oral Antitumor Drugs and Medication Safety in Uro-Oncology: Implications for Clinical Practice Based on a Subgroup Analysis of the AMBORA Trial |
title_full | New Oral Antitumor Drugs and Medication Safety in Uro-Oncology: Implications for Clinical Practice Based on a Subgroup Analysis of the AMBORA Trial |
title_fullStr | New Oral Antitumor Drugs and Medication Safety in Uro-Oncology: Implications for Clinical Practice Based on a Subgroup Analysis of the AMBORA Trial |
title_full_unstemmed | New Oral Antitumor Drugs and Medication Safety in Uro-Oncology: Implications for Clinical Practice Based on a Subgroup Analysis of the AMBORA Trial |
title_short | New Oral Antitumor Drugs and Medication Safety in Uro-Oncology: Implications for Clinical Practice Based on a Subgroup Analysis of the AMBORA Trial |
title_sort | new oral antitumor drugs and medication safety in uro-oncology: implications for clinical practice based on a subgroup analysis of the ambora trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369799/ https://www.ncbi.nlm.nih.gov/pubmed/35956173 http://dx.doi.org/10.3390/jcm11154558 |
work_keys_str_mv | AT schlichtigkatja neworalantitumordrugsandmedicationsafetyinurooncologyimplicationsforclinicalpracticebasedonasubgroupanalysisoftheamboratrial AT cubalisa neworalantitumordrugsandmedicationsafetyinurooncologyimplicationsforclinicalpracticebasedonasubgroupanalysisoftheamboratrial AT durrpauline neworalantitumordrugsandmedicationsafetyinurooncologyimplicationsforclinicalpracticebasedonasubgroupanalysisoftheamboratrial AT bellutlaura neworalantitumordrugsandmedicationsafetyinurooncologyimplicationsforclinicalpracticebasedonasubgroupanalysisoftheamboratrial AT meidenbauernorbert neworalantitumordrugsandmedicationsafetyinurooncologyimplicationsforclinicalpracticebasedonasubgroupanalysisoftheamboratrial AT kunathfrank neworalantitumordrugsandmedicationsafetyinurooncologyimplicationsforclinicalpracticebasedonasubgroupanalysisoftheamboratrial AT goebellpeterj neworalantitumordrugsandmedicationsafetyinurooncologyimplicationsforclinicalpracticebasedonasubgroupanalysisoftheamboratrial AT mackensenandreas neworalantitumordrugsandmedicationsafetyinurooncologyimplicationsforclinicalpracticebasedonasubgroupanalysisoftheamboratrial AT dorjefrank neworalantitumordrugsandmedicationsafetyinurooncologyimplicationsforclinicalpracticebasedonasubgroupanalysisoftheamboratrial AT frommmartinf neworalantitumordrugsandmedicationsafetyinurooncologyimplicationsforclinicalpracticebasedonasubgroupanalysisoftheamboratrial AT wullichbernd neworalantitumordrugsandmedicationsafetyinurooncologyimplicationsforclinicalpracticebasedonasubgroupanalysisoftheamboratrial |