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Signs and Symptoms of Acute Bowel Inflammation and the Risk of Progression to Inflammatory Bowel Disease: A Retrospective Analysis

Episodes of acute ileitis or colitis have been associated with future development of inflammatory bowel diseases (IBD). Nevertheless, the rate of future IBD among patients diagnosed with signs or symptoms of acute bowel inflammation is unknown. We aimed to assess the risk of IBD development among pa...

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Autores principales: Levartovsky, Asaf, Ovdat, Tal, Barash, Yiftach, Ben-Shatach, Zohar, Skinezes, Yael, Jesin, Stuart, Klempfner, Robert, Grossman, Ehud, Kopylov, Uri, Ben-Horin, Shomron, Ungar, Bella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369956/
https://www.ncbi.nlm.nih.gov/pubmed/35956209
http://dx.doi.org/10.3390/jcm11154595
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author Levartovsky, Asaf
Ovdat, Tal
Barash, Yiftach
Ben-Shatach, Zohar
Skinezes, Yael
Jesin, Stuart
Klempfner, Robert
Grossman, Ehud
Kopylov, Uri
Ben-Horin, Shomron
Ungar, Bella
author_facet Levartovsky, Asaf
Ovdat, Tal
Barash, Yiftach
Ben-Shatach, Zohar
Skinezes, Yael
Jesin, Stuart
Klempfner, Robert
Grossman, Ehud
Kopylov, Uri
Ben-Horin, Shomron
Ungar, Bella
author_sort Levartovsky, Asaf
collection PubMed
description Episodes of acute ileitis or colitis have been associated with future development of inflammatory bowel diseases (IBD). Nevertheless, the rate of future IBD among patients diagnosed with signs or symptoms of acute bowel inflammation is unknown. We aimed to assess the risk of IBD development among patients presenting with signs or symptoms of ileitis or colitis. We searched for all patients that visited the emergency department (ED) and underwent abdominal computed tomography (CT) who were eventually diagnosed with IBD during gastroenterology follow-ups within 9 years from the index admission. Multivariable models identified possible predictors of patients to develop IBD. Overall, 488 patients visited the ED and underwent abdominal imaging with abnormal findings, and 23 patients (4.7%) were eventually diagnosed with IBD (19 Crohn’s, 4 ulcerative colitis). Patients with a future IBD diagnosis were significantly younger (28 vs. 56 years, p < 0.001) with higher rates of diarrhea as a presenting symptom (17.4% vs. 4.1%, p = 0.015) compared to non-IBD patients. On multivariable analysis, age (p < 0.001), colitis (p = 0.004) or enteritis (p < 0.001) on imaging and a diagnosis of diarrhea in the ED (p = 0.02) were associated with development of IBD. Although alarming to patients and families, ED admission with intestinal inflammatory symptoms leads to eventual diagnosis of IBD in <5% of patients during long-term follow-up.
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spelling pubmed-93699562022-08-12 Signs and Symptoms of Acute Bowel Inflammation and the Risk of Progression to Inflammatory Bowel Disease: A Retrospective Analysis Levartovsky, Asaf Ovdat, Tal Barash, Yiftach Ben-Shatach, Zohar Skinezes, Yael Jesin, Stuart Klempfner, Robert Grossman, Ehud Kopylov, Uri Ben-Horin, Shomron Ungar, Bella J Clin Med Article Episodes of acute ileitis or colitis have been associated with future development of inflammatory bowel diseases (IBD). Nevertheless, the rate of future IBD among patients diagnosed with signs or symptoms of acute bowel inflammation is unknown. We aimed to assess the risk of IBD development among patients presenting with signs or symptoms of ileitis or colitis. We searched for all patients that visited the emergency department (ED) and underwent abdominal computed tomography (CT) who were eventually diagnosed with IBD during gastroenterology follow-ups within 9 years from the index admission. Multivariable models identified possible predictors of patients to develop IBD. Overall, 488 patients visited the ED and underwent abdominal imaging with abnormal findings, and 23 patients (4.7%) were eventually diagnosed with IBD (19 Crohn’s, 4 ulcerative colitis). Patients with a future IBD diagnosis were significantly younger (28 vs. 56 years, p < 0.001) with higher rates of diarrhea as a presenting symptom (17.4% vs. 4.1%, p = 0.015) compared to non-IBD patients. On multivariable analysis, age (p < 0.001), colitis (p = 0.004) or enteritis (p < 0.001) on imaging and a diagnosis of diarrhea in the ED (p = 0.02) were associated with development of IBD. Although alarming to patients and families, ED admission with intestinal inflammatory symptoms leads to eventual diagnosis of IBD in <5% of patients during long-term follow-up. MDPI 2022-08-06 /pmc/articles/PMC9369956/ /pubmed/35956209 http://dx.doi.org/10.3390/jcm11154595 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Levartovsky, Asaf
Ovdat, Tal
Barash, Yiftach
Ben-Shatach, Zohar
Skinezes, Yael
Jesin, Stuart
Klempfner, Robert
Grossman, Ehud
Kopylov, Uri
Ben-Horin, Shomron
Ungar, Bella
Signs and Symptoms of Acute Bowel Inflammation and the Risk of Progression to Inflammatory Bowel Disease: A Retrospective Analysis
title Signs and Symptoms of Acute Bowel Inflammation and the Risk of Progression to Inflammatory Bowel Disease: A Retrospective Analysis
title_full Signs and Symptoms of Acute Bowel Inflammation and the Risk of Progression to Inflammatory Bowel Disease: A Retrospective Analysis
title_fullStr Signs and Symptoms of Acute Bowel Inflammation and the Risk of Progression to Inflammatory Bowel Disease: A Retrospective Analysis
title_full_unstemmed Signs and Symptoms of Acute Bowel Inflammation and the Risk of Progression to Inflammatory Bowel Disease: A Retrospective Analysis
title_short Signs and Symptoms of Acute Bowel Inflammation and the Risk of Progression to Inflammatory Bowel Disease: A Retrospective Analysis
title_sort signs and symptoms of acute bowel inflammation and the risk of progression to inflammatory bowel disease: a retrospective analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369956/
https://www.ncbi.nlm.nih.gov/pubmed/35956209
http://dx.doi.org/10.3390/jcm11154595
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