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Nicotine Inhibits the Cytotoxicity and Genotoxicity of NNK Mediated by CYP2A13 in BEAS-2B Cells

Both tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and nicotine can be metabolized by cytochrome P450 2A13 (CYP2A13). Previous studies have shown that nicotine has a potential inhibitory effect on the toxicity of NNK. However, due to the lack of CYP2A13 activity in...

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Detalles Bibliográficos
Autores principales:	Sun, Yulin, Wang, Hongjuan, Chen, Huan, Zhang, Sen, Li, Jun, Zhang, Jingni, Tian, Jianlu, Zhang, Youyu, Hou, Hongwei, Hu, Qingyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369970/ https://www.ncbi.nlm.nih.gov/pubmed/35956805 http://dx.doi.org/10.3390/molecules27154851

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