Cargando…

Novel 1,3-Thiazole Analogues with Potent Activity against Breast Cancer: A Design, Synthesis, In Vitro, and In Silico Study

Breast cancer is the most common cancer in women, responsible for over half a million deaths in 2020. Almost 75% of FDA-approved drugs are mainly nitrogen- and sulfur-containing heterocyclic compounds, implying the importance of such compounds in drug discovery. Among heterocycles, thiazole-based he...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salem, Manar G., El-Maaty, Dina M. Abu, El-Deen, Yassmina I. Mohey, Elesawy, Basem H., Askary, Ahmad El, Saleh, Asmaa, Saied, Essa M., Behery, Mohammed El
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370021/ https://www.ncbi.nlm.nih.gov/pubmed/35956848 http://dx.doi.org/10.3390/molecules27154898

Ejemplares similares

Syzygium aromaticum Extracts as a Potential Antibacterial Inhibitors against Clinical Isolates of Acinetobacter baumannii: An In-Silico-Supported In-Vitro Study
por: Mahmoud, Abdelhamed, et al.
Publicado: (2021)

Synthesis, Molecular Docking Studies and In Silico ADMET Screening of New Heterocycles Linked Thiazole Conjugates as Potent Anti-Hepatic Cancer Agents
por: Rashdan, Huda R. M., et al.
Publicado: (2021)

Novel Exopolysaccharide from Marine Bacillus subtilis with Broad Potential Biological Activities: Insights into Antioxidant, Anti-Inflammatory, Cytotoxicity, and Anti-Alzheimer Activity
por: Abdel-Wahab, Basel A., et al.
Publicado: (2022)

Development of Novel 1,3-Disubstituted-2-Thiohydantoin Analogues with Potent Anti-Inflammatory Activity; In Vitro and In Silico Assessments
por: Khirallah, Salma M., et al.
Publicado: (2022)

Synthesis and Molecular Docking Study of New Thiazole Derivatives as Potential Tubulin Polymerization Inhibitors
por: El-Abd, Azhar O., et al.
Publicado: (2022)

Novel 8-Methoxycoumarin-3-Carboxamides with potent anticancer activity against liver cancer via targeting caspase-3/7 and β-tubulin polymerization
por: Alzamami, Ahmad, et al.
Publicado: (2023)

Impact of preconditioning stem cells with all-trans retinoic acid signaling pathway on cisplatin-induced nephrotoxicity by down-regulation of TGFβ1, IL-6, and caspase-3 and up-regulation of HIF1α and VEGF
por: Khedr, Mohsen, et al.
Publicado: (2022)

In Silico Identification of Structure Requirement for Novel Thiazole and Oxazole Derivatives as Potent Fructose 1,6-Bisphosphatase Inhibitors
por: Hao, Ming, et al.
Publicado: (2011)

Lignocellulosic Based Biochar Adsorbents for the Removal of Fluoride and Arsenic from Aqueous Solution: Isotherm and Kinetic Modeling
por: Ayaz, Iram, et al.
Publicado: (2022)

Synthesis, characterization, in silico molecular docking, and antibacterial activities of some new nitrogen-heterocyclic analogues based on a p-phenolic unit
por: Hussein, Abdel Haleem M., et al.
Publicado: (2022)

Facile One-Pot Multicomponent Synthesis of Pyrazolo-Thiazole Substituted Pyridines with Potential Anti-Proliferative Activity: Synthesis, In Vitro and In Silico Studies
por: El Azab, Islam H., et al.
Publicado: (2021)

New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
por: Carbone, Anna, et al.
Publicado: (2018)

Effects of 1,25(OH)(2)D(3) on Cancer Cells and Potential Applications in Combination with Established and Putative Anti-Cancer Agents
por: Abu el Maaty, Mohamed A., et al.
Publicado: (2017)

Vitamin D as a Novel Regulator of Tumor Metabolism: Insights on Potential Mechanisms and Implications for Anti-Cancer Therapy
por: Abu el Maaty, Mohamed A., et al.
Publicado: (2017)

Genetic diversity of common bean (Phaseolus vulgaris L.) ecotypes from Pakistan using Simple Sequence Repeats
por: Jannat, Sammyia, et al.
Publicado: (2022)

Protective Effects of Naringin–Dextrin Nanoformula against Chemically Induced Hepatocellular Carcinoma in Wistar Rats: Roles of Oxidative Stress, Inflammation, Cell Apoptosis, and Proliferation
por: Mohamed, Eman E., et al.
Publicado: (2022)

Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARγ, NF-κB, and PI3K/Akt Signaling Pathways
por: Yassin, Nour Y. S., et al.
Publicado: (2021)

Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study
por: Mohamed, Doaa I., et al.
Publicado: (2022)

Pancreatic gastrointestinal stromal tumor: A case report
por: Elgeidie, Ahmed, et al.
Publicado: (2016)

Halogen-containing thiazole orange analogues – new fluorogenic DNA stains
por: Vasilev, Aleksey A, et al.
Publicado: (2017)

Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation
por: Carbone, Anna, et al.
Publicado: (2020)

In Silico and In Vivo Evaluation of microRNA-181c-5p’s Role in Hepatocellular Carcinoma
por: Abd ElAziz, Omnia Nasser, et al.
Publicado: (2022)

Development of New Thiazole Complexes as Powerful Catalysts for Synthesis of Pyrazole-4-Carbonitrile Derivatives under Ultrasonic Irradiation Condition Supported by DFT Studies
por: Ali El-Remaily, Mahmoud Abd El Aleem Ali, et al.
Publicado: (2021)

Expression of TXNIP in Cancer Cells and Regulation by 1,25(OH)(2)D(3): Is It Really the Vitamin D(3) Upregulated Protein?
por: Abu el Maaty, Mohamed A., et al.
Publicado: (2018)

Impact of Obesity and Its Associated Comorbid Conditions on COVID-19 Presentation
por: Mehanna, Osama, et al.
Publicado: (2021)

The Synthesis, Fungicidal Activity, and in Silico Study of Alkoxy Analogues of Natural Precocenes I, II, and III
por: Ramadan, Khaled M. A., et al.
Publicado: (2022)

Comparative morphological interpretations on the bones of the pelvic limb of New Zealand rabbit (Oryctolagus cuniculus) and domestic cat (Felis domestica)
por: El-Ghazali, Hanaa Mohamed, et al.
Publicado: (2018)

Potential Mechanisms Involved in the Protective Effect of Dicaffeoylquinic Acids from Artemisia annua L. Leaves against Diabetes and Its Complications
por: El-Askary, Hesham, et al.
Publicado: (2022)

Evaluation of Pediatric Early Warning System and Drooling Reluctance Oropharynx Others Leukocytosis scores as prognostic tools for pediatric caustic ingestion: a two-center, cross-sectional study
por: Sharif, Asmaa Fady, et al.
Publicado: (2021)

Synthesis and in vitro antibacterial, antifungal, anti-proliferative activities of novel adamantane-containing thiazole compounds
por: Warda, Eman T., et al.
Publicado: (2022)

Gamma rays-assisted bacterial synthesis of bimetallic silver-selenium nanoparticles: powerful antimicrobial, antibiofilm, antioxidant, and photocatalytic activities
por: El-Behery, Reham R., et al.
Publicado: (2023)

Extramedullary Solitary Plasmacytoma with Anaplastic Features of the Nasopharynx
por: Padhi, Parikshit, et al.
Publicado: (2020)

Constrictive pericarditis caused by Cutibacterium (Propionibacterium) acnes: A case report and review of literature
por: Jensen, Troels Bek, et al.
Publicado: (2017)

New thiazole, pyridine and pyrazole derivatives as antioxidant candidates: synthesis, DFT calculations and molecular docking study
por: Kaddouri, Yassine, et al.
Publicado: (2020)

Deep Eutectic Solvents as Promising Green Solvents in Dispersive Liquid–Liquid Microextraction Based on Solidification of Floating Organic Droplet: Recent Applications, Challenges and Future Perspectives
por: El-Deen, Asmaa Kamal, et al.
Publicado: (2021)

Synthesis and Anticancer Evaluation of New Thiazole and Thiadiazole Derivatives Bearing Acetanilide Moiety
por: El-Rayyes, Ali, et al.
Publicado: (2022)

Delineating a potent antiviral activity of Cuphea ignea extract loaded nano-formulation against SARS-CoV-2: In silico and in vitro studies
por: Mahmoud, Dina B., et al.
Publicado: (2021)

Acetylsalicylic Acid Suppresses Alcoholism-Induced Cognitive Impairment Associated with Atorvastatin Intake by Targeting Cerebral miRNA155 and NLRP3: In Vivo, and In Silico Study
por: Mohamed, Doaa I., et al.
Publicado: (2022)

Nanoparticles of zinc oxide defeat chlorpyrifos-induced immunotoxic effects and histopathological alterations
por: Essa, Sara S., et al.
Publicado: (2019)

Subereamolline A as a Potent Breast Cancer Migration, Invasion and Proliferation Inhibitor and Bioactive Dibrominated Alkaloids from the Red Sea Sponge Pseudoceratina arabica
por: Shaala, Lamiaa A., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_6dbscjjfd28esp53etr0tjbp66