Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications

Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and promoting the resolution of inflammation. Our purpos...

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Detalles Bibliográficos
Autores principales: Valente, Mariarosaria, Dentoni, Marta, Bellizzi, Fabrizio, Kuris, Fedra, Gigli, Gian Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370036/
https://www.ncbi.nlm.nih.gov/pubmed/35956787
http://dx.doi.org/10.3390/molecules27154836
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author Valente, Mariarosaria
Dentoni, Marta
Bellizzi, Fabrizio
Kuris, Fedra
Gigli, Gian Luigi
author_facet Valente, Mariarosaria
Dentoni, Marta
Bellizzi, Fabrizio
Kuris, Fedra
Gigli, Gian Luigi
author_sort Valente, Mariarosaria
collection PubMed
description Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and promoting the resolution of inflammation. Our purpose was to point out the current evidence for specialized pro-resolving mediators, focusing on their role in neuroinflammation and in major neurological diseases.
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spelling pubmed-93700362022-08-12 Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications Valente, Mariarosaria Dentoni, Marta Bellizzi, Fabrizio Kuris, Fedra Gigli, Gian Luigi Molecules Review Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and promoting the resolution of inflammation. Our purpose was to point out the current evidence for specialized pro-resolving mediators, focusing on their role in neuroinflammation and in major neurological diseases. MDPI 2022-07-28 /pmc/articles/PMC9370036/ /pubmed/35956787 http://dx.doi.org/10.3390/molecules27154836 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Valente, Mariarosaria
Dentoni, Marta
Bellizzi, Fabrizio
Kuris, Fedra
Gigli, Gian Luigi
Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications
title Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications
title_full Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications
title_fullStr Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications
title_full_unstemmed Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications
title_short Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications
title_sort specialized pro-resolving mediators in neuroinflammation: overview of studies and perspectives of clinical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370036/
https://www.ncbi.nlm.nih.gov/pubmed/35956787
http://dx.doi.org/10.3390/molecules27154836
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