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Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review

Ketone bodies (KBs) and Sirtuin-1 (SIRT1) have received increasing attention over the past two decades given their pivotal function in a variety of biological contexts, including transcriptional regulation, cell cycle progression, inflammation, metabolism, neurological and cardiovascular physiology,...

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Autores principales: Tozzi, Rossella, Cipriani, Fiammetta, Masi, Davide, Basciani, Sabrina, Watanabe, Mikiko, Lubrano, Carla, Gnessi, Lucio, Mariani, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370141/
https://www.ncbi.nlm.nih.gov/pubmed/35956321
http://dx.doi.org/10.3390/nu14153145
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author Tozzi, Rossella
Cipriani, Fiammetta
Masi, Davide
Basciani, Sabrina
Watanabe, Mikiko
Lubrano, Carla
Gnessi, Lucio
Mariani, Stefania
author_facet Tozzi, Rossella
Cipriani, Fiammetta
Masi, Davide
Basciani, Sabrina
Watanabe, Mikiko
Lubrano, Carla
Gnessi, Lucio
Mariani, Stefania
author_sort Tozzi, Rossella
collection PubMed
description Ketone bodies (KBs) and Sirtuin-1 (SIRT1) have received increasing attention over the past two decades given their pivotal function in a variety of biological contexts, including transcriptional regulation, cell cycle progression, inflammation, metabolism, neurological and cardiovascular physiology, and cancer. As a consequence, the modulation of KBs and SIRT1 is considered a promising therapeutic option for many diseases. The direct regulation of gene expression can occur in vivo through histone modifications mediated by both SIRT1 and KBs during fasting or low-carbohydrate diets, and dietary metabolites may contribute to epigenetic regulation, leading to greater genomic plasticity. In this review, we provide an updated overview of the epigenetic interactions between KBs and SIRT1, with a particular glance at their central, synergistic roles for metabolic health.
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spelling pubmed-93701412022-08-12 Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review Tozzi, Rossella Cipriani, Fiammetta Masi, Davide Basciani, Sabrina Watanabe, Mikiko Lubrano, Carla Gnessi, Lucio Mariani, Stefania Nutrients Review Ketone bodies (KBs) and Sirtuin-1 (SIRT1) have received increasing attention over the past two decades given their pivotal function in a variety of biological contexts, including transcriptional regulation, cell cycle progression, inflammation, metabolism, neurological and cardiovascular physiology, and cancer. As a consequence, the modulation of KBs and SIRT1 is considered a promising therapeutic option for many diseases. The direct regulation of gene expression can occur in vivo through histone modifications mediated by both SIRT1 and KBs during fasting or low-carbohydrate diets, and dietary metabolites may contribute to epigenetic regulation, leading to greater genomic plasticity. In this review, we provide an updated overview of the epigenetic interactions between KBs and SIRT1, with a particular glance at their central, synergistic roles for metabolic health. MDPI 2022-07-30 /pmc/articles/PMC9370141/ /pubmed/35956321 http://dx.doi.org/10.3390/nu14153145 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tozzi, Rossella
Cipriani, Fiammetta
Masi, Davide
Basciani, Sabrina
Watanabe, Mikiko
Lubrano, Carla
Gnessi, Lucio
Mariani, Stefania
Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review
title Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review
title_full Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review
title_fullStr Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review
title_full_unstemmed Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review
title_short Ketone Bodies and SIRT1, Synergic Epigenetic Regulators for Metabolic Health: A Narrative Review
title_sort ketone bodies and sirt1, synergic epigenetic regulators for metabolic health: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370141/
https://www.ncbi.nlm.nih.gov/pubmed/35956321
http://dx.doi.org/10.3390/nu14153145
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