In Vitro and In Vivo Antibacterial Activity, Toxicity and Resistance Analysis of Pleuromutilin Derivative Z33 against Methicillin-Resistant Staphylococcus aureus

The novel pleuromutilin derivative, which showed excellent in vitro antibacterial activity against MRSA, 22-(2-(2-(4-((4-(4-nitrophenyl)piperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)acetamido)phenyl)thioacety-l-yl-22-deoxypleuromutilin (Z33), was synthesized and characterized in our previous work. In...

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Detalles Bibliográficos
Autores principales: Hu, Yuhan, Chen, Fang, Zhou, Kexin, Zhang, Zhe, Li, Fei, Zhang, Jianfeng, Tang, Youzhi, Jin, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370166/
https://www.ncbi.nlm.nih.gov/pubmed/35956888
http://dx.doi.org/10.3390/molecules27154939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370166/
https://www.ncbi.nlm.nih.gov/pubmed/35956888
http://dx.doi.org/10.3390/molecules27154939

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