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HIF in Gastric Cancer: Regulation and Therapeutic Target
HIF means hypoxia-inducible factor gene family, and it could regulate various biological processes, including tumor development. In 2021, the FDA approved the new drug Welireg for targeting HIF-2a, and it is mainly used to treat von Hippel-Lindau syndrome, which demonstrated its good prospects in tu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370240/ https://www.ncbi.nlm.nih.gov/pubmed/35956843 http://dx.doi.org/10.3390/molecules27154893 |
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author | Li, Mengqing Li, Guan Yang, Xiaodong Yin, Weihua Lv, Guoqing Wang, Shubin |
author_facet | Li, Mengqing Li, Guan Yang, Xiaodong Yin, Weihua Lv, Guoqing Wang, Shubin |
author_sort | Li, Mengqing |
collection | PubMed |
description | HIF means hypoxia-inducible factor gene family, and it could regulate various biological processes, including tumor development. In 2021, the FDA approved the new drug Welireg for targeting HIF-2a, and it is mainly used to treat von Hippel-Lindau syndrome, which demonstrated its good prospects in tumor therapy. As the fourth deadliest cancer worldwide, gastric cancer endangers the health of people all across the world. Currently, there are various treatment methods for patients with gastric cancer, but the five-year survival rate of patients with advanced gastric cancer is still not high. Therefore, here we reviewed the regulatory role and target role of HIF in gastric cancer, and provided some references for the treatment of gastric cancer. |
format | Online Article Text |
id | pubmed-9370240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93702402022-08-12 HIF in Gastric Cancer: Regulation and Therapeutic Target Li, Mengqing Li, Guan Yang, Xiaodong Yin, Weihua Lv, Guoqing Wang, Shubin Molecules Review HIF means hypoxia-inducible factor gene family, and it could regulate various biological processes, including tumor development. In 2021, the FDA approved the new drug Welireg for targeting HIF-2a, and it is mainly used to treat von Hippel-Lindau syndrome, which demonstrated its good prospects in tumor therapy. As the fourth deadliest cancer worldwide, gastric cancer endangers the health of people all across the world. Currently, there are various treatment methods for patients with gastric cancer, but the five-year survival rate of patients with advanced gastric cancer is still not high. Therefore, here we reviewed the regulatory role and target role of HIF in gastric cancer, and provided some references for the treatment of gastric cancer. MDPI 2022-07-31 /pmc/articles/PMC9370240/ /pubmed/35956843 http://dx.doi.org/10.3390/molecules27154893 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Li, Mengqing Li, Guan Yang, Xiaodong Yin, Weihua Lv, Guoqing Wang, Shubin HIF in Gastric Cancer: Regulation and Therapeutic Target |
title | HIF in Gastric Cancer: Regulation and Therapeutic Target |
title_full | HIF in Gastric Cancer: Regulation and Therapeutic Target |
title_fullStr | HIF in Gastric Cancer: Regulation and Therapeutic Target |
title_full_unstemmed | HIF in Gastric Cancer: Regulation and Therapeutic Target |
title_short | HIF in Gastric Cancer: Regulation and Therapeutic Target |
title_sort | hif in gastric cancer: regulation and therapeutic target |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370240/ https://www.ncbi.nlm.nih.gov/pubmed/35956843 http://dx.doi.org/10.3390/molecules27154893 |
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