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HIF in Gastric Cancer: Regulation and Therapeutic Target

HIF means hypoxia-inducible factor gene family, and it could regulate various biological processes, including tumor development. In 2021, the FDA approved the new drug Welireg for targeting HIF-2a, and it is mainly used to treat von Hippel-Lindau syndrome, which demonstrated its good prospects in tu...

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Detalles Bibliográficos
Autores principales: Li, Mengqing, Li, Guan, Yang, Xiaodong, Yin, Weihua, Lv, Guoqing, Wang, Shubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370240/
https://www.ncbi.nlm.nih.gov/pubmed/35956843
http://dx.doi.org/10.3390/molecules27154893
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author Li, Mengqing
Li, Guan
Yang, Xiaodong
Yin, Weihua
Lv, Guoqing
Wang, Shubin
author_facet Li, Mengqing
Li, Guan
Yang, Xiaodong
Yin, Weihua
Lv, Guoqing
Wang, Shubin
author_sort Li, Mengqing
collection PubMed
description HIF means hypoxia-inducible factor gene family, and it could regulate various biological processes, including tumor development. In 2021, the FDA approved the new drug Welireg for targeting HIF-2a, and it is mainly used to treat von Hippel-Lindau syndrome, which demonstrated its good prospects in tumor therapy. As the fourth deadliest cancer worldwide, gastric cancer endangers the health of people all across the world. Currently, there are various treatment methods for patients with gastric cancer, but the five-year survival rate of patients with advanced gastric cancer is still not high. Therefore, here we reviewed the regulatory role and target role of HIF in gastric cancer, and provided some references for the treatment of gastric cancer.
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spelling pubmed-93702402022-08-12 HIF in Gastric Cancer: Regulation and Therapeutic Target Li, Mengqing Li, Guan Yang, Xiaodong Yin, Weihua Lv, Guoqing Wang, Shubin Molecules Review HIF means hypoxia-inducible factor gene family, and it could regulate various biological processes, including tumor development. In 2021, the FDA approved the new drug Welireg for targeting HIF-2a, and it is mainly used to treat von Hippel-Lindau syndrome, which demonstrated its good prospects in tumor therapy. As the fourth deadliest cancer worldwide, gastric cancer endangers the health of people all across the world. Currently, there are various treatment methods for patients with gastric cancer, but the five-year survival rate of patients with advanced gastric cancer is still not high. Therefore, here we reviewed the regulatory role and target role of HIF in gastric cancer, and provided some references for the treatment of gastric cancer. MDPI 2022-07-31 /pmc/articles/PMC9370240/ /pubmed/35956843 http://dx.doi.org/10.3390/molecules27154893 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Mengqing
Li, Guan
Yang, Xiaodong
Yin, Weihua
Lv, Guoqing
Wang, Shubin
HIF in Gastric Cancer: Regulation and Therapeutic Target
title HIF in Gastric Cancer: Regulation and Therapeutic Target
title_full HIF in Gastric Cancer: Regulation and Therapeutic Target
title_fullStr HIF in Gastric Cancer: Regulation and Therapeutic Target
title_full_unstemmed HIF in Gastric Cancer: Regulation and Therapeutic Target
title_short HIF in Gastric Cancer: Regulation and Therapeutic Target
title_sort hif in gastric cancer: regulation and therapeutic target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370240/
https://www.ncbi.nlm.nih.gov/pubmed/35956843
http://dx.doi.org/10.3390/molecules27154893
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