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Application of Cleavable Linkers to Improve Therapeutic Index of Radioligand Therapies

Radioligand therapy (RLT) is an emergent drug class for cancer treatment. The dose administered to cancer patients is constrained by the radiation exposure to normal tissues to maintain an appropriate therapeutic index. When a radiopharmaceutical or its radiometabolite is retained in the kidneys, ra...

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Detalles Bibliográficos
Autores principales:	Lau, Joseph, Lee, Hwan, Rousseau, Julie, Bénard, François, Lin, Kuo-Shyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370263/ https://www.ncbi.nlm.nih.gov/pubmed/35956909 http://dx.doi.org/10.3390/molecules27154959

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