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Association of Vitamin D Supplementation with Cardiovascular Events: A Systematic Review and Meta-Analysis
Background: low vitamin D status has been associated with an increased incidence of cardiovascular events. However, whether vitamin D supplementation would reduce the incidence of cardiovascular events remains unclear. Purpose: To perform a systematic review and meta-analysis of the effect of vitami...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370368/ https://www.ncbi.nlm.nih.gov/pubmed/35956336 http://dx.doi.org/10.3390/nu14153158 |
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author | Pei, Yi-Yan Zhang, Yu Peng, Xing-Chen Liu, Zhe-Ran Xu, Ping Fang, Fang |
author_facet | Pei, Yi-Yan Zhang, Yu Peng, Xing-Chen Liu, Zhe-Ran Xu, Ping Fang, Fang |
author_sort | Pei, Yi-Yan |
collection | PubMed |
description | Background: low vitamin D status has been associated with an increased incidence of cardiovascular events. However, whether vitamin D supplementation would reduce the incidence of cardiovascular events remains unclear. Purpose: To perform a systematic review and meta-analysis of the effect of vitamin D supplementation on the mortality and incidence of cardiovascular events. Data Sources: We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials from their inception until 3 May 2022. Study Selection: Two authors searched for randomized clinical trials that reported vitamin D supplementation’s effect on cardiovascular events outcomes. Data Extraction: Two authors conducted independent data extraction. Data Synthesis: We identified 41,809 reports; after exclusions, 18 trials with a total of 70,278 participants were eligible for analysis. Vitamin D supplementation was not associated with the mortality of cardiovascular events (RR 0.96, 95% CI 0.88–1.06, I(2) = 0%), the incidence of stroke (RR 1.05, 95% CI 0.92–1.20, I(2) = 0%), myocardial infarction (RR 0.97, 95% CI 0.87–1.09, I(2) = 0%), total cardiovascular events (RR 0.97, 95% CI 0.91–1.04, I(2) = 27%), or cerebrovascular events (RR 1.01, 95% CI 0.87–1.18, I(2) = 0%). Limitation: Cardiovascular events were the secondary outcome in most trials and thus, might be selectively reported. Conclusion: In this meta-analysis of randomized clinical trials, vitamin D supplementation was not associated with a lower risk of cardiovascular events than no supplementation. These findings do not support the routine use of vitamin D supplementation in general. |
format | Online Article Text |
id | pubmed-9370368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93703682022-08-12 Association of Vitamin D Supplementation with Cardiovascular Events: A Systematic Review and Meta-Analysis Pei, Yi-Yan Zhang, Yu Peng, Xing-Chen Liu, Zhe-Ran Xu, Ping Fang, Fang Nutrients Article Background: low vitamin D status has been associated with an increased incidence of cardiovascular events. However, whether vitamin D supplementation would reduce the incidence of cardiovascular events remains unclear. Purpose: To perform a systematic review and meta-analysis of the effect of vitamin D supplementation on the mortality and incidence of cardiovascular events. Data Sources: We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials from their inception until 3 May 2022. Study Selection: Two authors searched for randomized clinical trials that reported vitamin D supplementation’s effect on cardiovascular events outcomes. Data Extraction: Two authors conducted independent data extraction. Data Synthesis: We identified 41,809 reports; after exclusions, 18 trials with a total of 70,278 participants were eligible for analysis. Vitamin D supplementation was not associated with the mortality of cardiovascular events (RR 0.96, 95% CI 0.88–1.06, I(2) = 0%), the incidence of stroke (RR 1.05, 95% CI 0.92–1.20, I(2) = 0%), myocardial infarction (RR 0.97, 95% CI 0.87–1.09, I(2) = 0%), total cardiovascular events (RR 0.97, 95% CI 0.91–1.04, I(2) = 27%), or cerebrovascular events (RR 1.01, 95% CI 0.87–1.18, I(2) = 0%). Limitation: Cardiovascular events were the secondary outcome in most trials and thus, might be selectively reported. Conclusion: In this meta-analysis of randomized clinical trials, vitamin D supplementation was not associated with a lower risk of cardiovascular events than no supplementation. These findings do not support the routine use of vitamin D supplementation in general. MDPI 2022-07-30 /pmc/articles/PMC9370368/ /pubmed/35956336 http://dx.doi.org/10.3390/nu14153158 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pei, Yi-Yan Zhang, Yu Peng, Xing-Chen Liu, Zhe-Ran Xu, Ping Fang, Fang Association of Vitamin D Supplementation with Cardiovascular Events: A Systematic Review and Meta-Analysis |
title | Association of Vitamin D Supplementation with Cardiovascular Events: A Systematic Review and Meta-Analysis |
title_full | Association of Vitamin D Supplementation with Cardiovascular Events: A Systematic Review and Meta-Analysis |
title_fullStr | Association of Vitamin D Supplementation with Cardiovascular Events: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Association of Vitamin D Supplementation with Cardiovascular Events: A Systematic Review and Meta-Analysis |
title_short | Association of Vitamin D Supplementation with Cardiovascular Events: A Systematic Review and Meta-Analysis |
title_sort | association of vitamin d supplementation with cardiovascular events: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370368/ https://www.ncbi.nlm.nih.gov/pubmed/35956336 http://dx.doi.org/10.3390/nu14153158 |
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