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Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders

The longstanding progressive neurodegenerative conditions of the central nervous system arise mainly due to deterioration, degradation and eventual neuronal cell loss. As an individual ages, the irreversible neurodegenerative disorders associated with aging also begin to develop, and these have beco...

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Autores principales: Behl, Tapan, Makkar, Rashita, Sehgal, Aayush, Sharma, Neelam, Singh, Sukhbir, Albratty, Mohammed, Najmi, Asim, Meraya, Abdulkarim M., Bungau, Simona Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370592/
https://www.ncbi.nlm.nih.gov/pubmed/35956919
http://dx.doi.org/10.3390/molecules27154970
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author Behl, Tapan
Makkar, Rashita
Sehgal, Aayush
Sharma, Neelam
Singh, Sukhbir
Albratty, Mohammed
Najmi, Asim
Meraya, Abdulkarim M.
Bungau, Simona Gabriela
author_facet Behl, Tapan
Makkar, Rashita
Sehgal, Aayush
Sharma, Neelam
Singh, Sukhbir
Albratty, Mohammed
Najmi, Asim
Meraya, Abdulkarim M.
Bungau, Simona Gabriela
author_sort Behl, Tapan
collection PubMed
description The longstanding progressive neurodegenerative conditions of the central nervous system arise mainly due to deterioration, degradation and eventual neuronal cell loss. As an individual ages, the irreversible neurodegenerative disorders associated with aging also begin to develop, and these have become exceedingly prominent and pose a significant burden mentally, socially and economically on both the individual and their family. These disorders express several symptoms, such as tremors, dystonia, loss of cognitive functions, impairment of motor activity leading to immobility, loss of memory and many more which worsen with time. The treatment employed in management of these debilitating neurodegenerative disorders, such as Parkinson’s disease (which mainly involves the loss of dopaminergic neurons in the nigrostriatal region), Alzheimer’s disease (which arises due to accumulation of Tau proteins causing diffusive atrophy in the brain), Huntington’s disease (which involves damage of striatal and spinal neurons, etc.), have several adverse effects, leading to exploration of several lead targets and molecules existing in herbal drugs. The current review highlights the mechanistic role of natural products in the treatment of several neurodegenerative and cerebrovascular diseases such as Parkinson’s disease, Alzheimer’s disease, ischemic stroke and depression.
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spelling pubmed-93705922022-08-12 Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders Behl, Tapan Makkar, Rashita Sehgal, Aayush Sharma, Neelam Singh, Sukhbir Albratty, Mohammed Najmi, Asim Meraya, Abdulkarim M. Bungau, Simona Gabriela Molecules Review The longstanding progressive neurodegenerative conditions of the central nervous system arise mainly due to deterioration, degradation and eventual neuronal cell loss. As an individual ages, the irreversible neurodegenerative disorders associated with aging also begin to develop, and these have become exceedingly prominent and pose a significant burden mentally, socially and economically on both the individual and their family. These disorders express several symptoms, such as tremors, dystonia, loss of cognitive functions, impairment of motor activity leading to immobility, loss of memory and many more which worsen with time. The treatment employed in management of these debilitating neurodegenerative disorders, such as Parkinson’s disease (which mainly involves the loss of dopaminergic neurons in the nigrostriatal region), Alzheimer’s disease (which arises due to accumulation of Tau proteins causing diffusive atrophy in the brain), Huntington’s disease (which involves damage of striatal and spinal neurons, etc.), have several adverse effects, leading to exploration of several lead targets and molecules existing in herbal drugs. The current review highlights the mechanistic role of natural products in the treatment of several neurodegenerative and cerebrovascular diseases such as Parkinson’s disease, Alzheimer’s disease, ischemic stroke and depression. MDPI 2022-08-04 /pmc/articles/PMC9370592/ /pubmed/35956919 http://dx.doi.org/10.3390/molecules27154970 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Behl, Tapan
Makkar, Rashita
Sehgal, Aayush
Sharma, Neelam
Singh, Sukhbir
Albratty, Mohammed
Najmi, Asim
Meraya, Abdulkarim M.
Bungau, Simona Gabriela
Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders
title Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders
title_full Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders
title_fullStr Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders
title_full_unstemmed Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders
title_short Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders
title_sort insights into the explicit protective activity of herbals in management of neurodegenerative and cerebrovascular disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370592/
https://www.ncbi.nlm.nih.gov/pubmed/35956919
http://dx.doi.org/10.3390/molecules27154970
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