The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2

The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19. The high efficacy of the combinations in reducing virus titer in lungs and body weight loss and in...

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Autores principales: Ivashchenko, Andrey A., Zagribelnyy, Bogdan A., Ivanenkov, Yan A., Ivashchenko, Ilya A., Karapetian, Ruben N., Kravchenko, Dmitry V., Savchuk, Nikolay P., Yakubova, Elena V., Ivachtchenko, Alexandre V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370800/
https://www.ncbi.nlm.nih.gov/pubmed/35956925
http://dx.doi.org/10.3390/molecules27154975
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author Ivashchenko, Andrey A.
Zagribelnyy, Bogdan A.
Ivanenkov, Yan A.
Ivashchenko, Ilya A.
Karapetian, Ruben N.
Kravchenko, Dmitry V.
Savchuk, Nikolay P.
Yakubova, Elena V.
Ivachtchenko, Alexandre V.
author_facet Ivashchenko, Andrey A.
Zagribelnyy, Bogdan A.
Ivanenkov, Yan A.
Ivashchenko, Ilya A.
Karapetian, Ruben N.
Kravchenko, Dmitry V.
Savchuk, Nikolay P.
Yakubova, Elena V.
Ivachtchenko, Alexandre V.
author_sort Ivashchenko, Andrey A.
collection PubMed
description The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19. The high efficacy of the combinations in reducing virus titer in lungs and body weight loss and in increasing the survival rate were demonstrated. This preclinical study can be considered a confirmatory step before introducing the combinations into clinical assessment.
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spelling pubmed-93708002022-08-12 The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2 Ivashchenko, Andrey A. Zagribelnyy, Bogdan A. Ivanenkov, Yan A. Ivashchenko, Ilya A. Karapetian, Ruben N. Kravchenko, Dmitry V. Savchuk, Nikolay P. Yakubova, Elena V. Ivachtchenko, Alexandre V. Molecules Article The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19. The high efficacy of the combinations in reducing virus titer in lungs and body weight loss and in increasing the survival rate were demonstrated. This preclinical study can be considered a confirmatory step before introducing the combinations into clinical assessment. MDPI 2022-08-05 /pmc/articles/PMC9370800/ /pubmed/35956925 http://dx.doi.org/10.3390/molecules27154975 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ivashchenko, Andrey A.
Zagribelnyy, Bogdan A.
Ivanenkov, Yan A.
Ivashchenko, Ilya A.
Karapetian, Ruben N.
Kravchenko, Dmitry V.
Savchuk, Nikolay P.
Yakubova, Elena V.
Ivachtchenko, Alexandre V.
The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2
title The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2
title_full The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2
title_fullStr The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2
title_full_unstemmed The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2
title_short The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2
title_sort efficacy of aprotinin combinations with selected antiviral drugs in mouse models of influenza pneumonia and coronavirus infection caused by sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370800/
https://www.ncbi.nlm.nih.gov/pubmed/35956925
http://dx.doi.org/10.3390/molecules27154975
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