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Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study
Tobacco smoke exposure is known to lower serum 25-hydroxyvitamin D (25(OH)D) concentrations. This study evaluated the association between passive smoking and vitamin D deficiency (VDD) in young children using data from the Japan Environment and Children’s Study (JECS), the largest birth cohort study...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370804/ https://www.ncbi.nlm.nih.gov/pubmed/35956297 http://dx.doi.org/10.3390/nu14153121 |
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author | Yang, Limin Sato, Miori Saito-Abe, Mayako Miyaji, Yumiko Sato, Chikako Nishizato, Minaho Kumasaka, Natsuhiko Mezawa, Hidetoshi Yamamoto-Hanada, Kiwako Ohya, Yukihiro |
author_facet | Yang, Limin Sato, Miori Saito-Abe, Mayako Miyaji, Yumiko Sato, Chikako Nishizato, Minaho Kumasaka, Natsuhiko Mezawa, Hidetoshi Yamamoto-Hanada, Kiwako Ohya, Yukihiro |
author_sort | Yang, Limin |
collection | PubMed |
description | Tobacco smoke exposure is known to lower serum 25-hydroxyvitamin D (25(OH)D) concentrations. This study evaluated the association between passive smoking and vitamin D deficiency (VDD) in young children using data from the Japan Environment and Children’s Study (JECS), the largest birth cohort study in Japan. Information on parental smoking status was extracted from a survey of JECS for children aged 1.5 years and data for serum 25(OH)D concentrations were obtained from blood tests in the Sub-Cohort Study of JECS performed at age 2 years. Logistic regression and linear models were fitted to evaluate the association between these variables. Data were analyzed for 4593 children. After adjusting for covariates, smoke exposure was significantly associated with increased incidence of VDD (OR 1.35; 95% CI, 1.14–1.59) according to the logistic model. The linear model indicated that passive smoking negatively predicted de-seasonalized serum 25(OH)D concentrations (β −0.5; 95% CI −0.95 to −0.08) in children aged 2 years. The results suggest that smoke exposure is a risk factor for VDD in children. Given that VD plays a crucial role in bone metabolism and the immune system, our findings are significant for clinical and public health. |
format | Online Article Text |
id | pubmed-9370804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93708042022-08-12 Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study Yang, Limin Sato, Miori Saito-Abe, Mayako Miyaji, Yumiko Sato, Chikako Nishizato, Minaho Kumasaka, Natsuhiko Mezawa, Hidetoshi Yamamoto-Hanada, Kiwako Ohya, Yukihiro Nutrients Article Tobacco smoke exposure is known to lower serum 25-hydroxyvitamin D (25(OH)D) concentrations. This study evaluated the association between passive smoking and vitamin D deficiency (VDD) in young children using data from the Japan Environment and Children’s Study (JECS), the largest birth cohort study in Japan. Information on parental smoking status was extracted from a survey of JECS for children aged 1.5 years and data for serum 25(OH)D concentrations were obtained from blood tests in the Sub-Cohort Study of JECS performed at age 2 years. Logistic regression and linear models were fitted to evaluate the association between these variables. Data were analyzed for 4593 children. After adjusting for covariates, smoke exposure was significantly associated with increased incidence of VDD (OR 1.35; 95% CI, 1.14–1.59) according to the logistic model. The linear model indicated that passive smoking negatively predicted de-seasonalized serum 25(OH)D concentrations (β −0.5; 95% CI −0.95 to −0.08) in children aged 2 years. The results suggest that smoke exposure is a risk factor for VDD in children. Given that VD plays a crucial role in bone metabolism and the immune system, our findings are significant for clinical and public health. MDPI 2022-07-29 /pmc/articles/PMC9370804/ /pubmed/35956297 http://dx.doi.org/10.3390/nu14153121 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yang, Limin Sato, Miori Saito-Abe, Mayako Miyaji, Yumiko Sato, Chikako Nishizato, Minaho Kumasaka, Natsuhiko Mezawa, Hidetoshi Yamamoto-Hanada, Kiwako Ohya, Yukihiro Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study |
title | Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study |
title_full | Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study |
title_fullStr | Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study |
title_full_unstemmed | Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study |
title_short | Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study |
title_sort | smoking exposure is associated with serum vitamin d deficiency in children: evidence from the japan environment and children’s study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370804/ https://www.ncbi.nlm.nih.gov/pubmed/35956297 http://dx.doi.org/10.3390/nu14153121 |
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