Cargando…

Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study

Tobacco smoke exposure is known to lower serum 25-hydroxyvitamin D (25(OH)D) concentrations. This study evaluated the association between passive smoking and vitamin D deficiency (VDD) in young children using data from the Japan Environment and Children’s Study (JECS), the largest birth cohort study...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Limin, Sato, Miori, Saito-Abe, Mayako, Miyaji, Yumiko, Sato, Chikako, Nishizato, Minaho, Kumasaka, Natsuhiko, Mezawa, Hidetoshi, Yamamoto-Hanada, Kiwako, Ohya, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370804/
https://www.ncbi.nlm.nih.gov/pubmed/35956297
http://dx.doi.org/10.3390/nu14153121
_version_ 1784766926186086400
author Yang, Limin
Sato, Miori
Saito-Abe, Mayako
Miyaji, Yumiko
Sato, Chikako
Nishizato, Minaho
Kumasaka, Natsuhiko
Mezawa, Hidetoshi
Yamamoto-Hanada, Kiwako
Ohya, Yukihiro
author_facet Yang, Limin
Sato, Miori
Saito-Abe, Mayako
Miyaji, Yumiko
Sato, Chikako
Nishizato, Minaho
Kumasaka, Natsuhiko
Mezawa, Hidetoshi
Yamamoto-Hanada, Kiwako
Ohya, Yukihiro
author_sort Yang, Limin
collection PubMed
description Tobacco smoke exposure is known to lower serum 25-hydroxyvitamin D (25(OH)D) concentrations. This study evaluated the association between passive smoking and vitamin D deficiency (VDD) in young children using data from the Japan Environment and Children’s Study (JECS), the largest birth cohort study in Japan. Information on parental smoking status was extracted from a survey of JECS for children aged 1.5 years and data for serum 25(OH)D concentrations were obtained from blood tests in the Sub-Cohort Study of JECS performed at age 2 years. Logistic regression and linear models were fitted to evaluate the association between these variables. Data were analyzed for 4593 children. After adjusting for covariates, smoke exposure was significantly associated with increased incidence of VDD (OR 1.35; 95% CI, 1.14–1.59) according to the logistic model. The linear model indicated that passive smoking negatively predicted de-seasonalized serum 25(OH)D concentrations (β −0.5; 95% CI −0.95 to −0.08) in children aged 2 years. The results suggest that smoke exposure is a risk factor for VDD in children. Given that VD plays a crucial role in bone metabolism and the immune system, our findings are significant for clinical and public health.
format Online
Article
Text
id pubmed-9370804
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93708042022-08-12 Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study Yang, Limin Sato, Miori Saito-Abe, Mayako Miyaji, Yumiko Sato, Chikako Nishizato, Minaho Kumasaka, Natsuhiko Mezawa, Hidetoshi Yamamoto-Hanada, Kiwako Ohya, Yukihiro Nutrients Article Tobacco smoke exposure is known to lower serum 25-hydroxyvitamin D (25(OH)D) concentrations. This study evaluated the association between passive smoking and vitamin D deficiency (VDD) in young children using data from the Japan Environment and Children’s Study (JECS), the largest birth cohort study in Japan. Information on parental smoking status was extracted from a survey of JECS for children aged 1.5 years and data for serum 25(OH)D concentrations were obtained from blood tests in the Sub-Cohort Study of JECS performed at age 2 years. Logistic regression and linear models were fitted to evaluate the association between these variables. Data were analyzed for 4593 children. After adjusting for covariates, smoke exposure was significantly associated with increased incidence of VDD (OR 1.35; 95% CI, 1.14–1.59) according to the logistic model. The linear model indicated that passive smoking negatively predicted de-seasonalized serum 25(OH)D concentrations (β −0.5; 95% CI −0.95 to −0.08) in children aged 2 years. The results suggest that smoke exposure is a risk factor for VDD in children. Given that VD plays a crucial role in bone metabolism and the immune system, our findings are significant for clinical and public health. MDPI 2022-07-29 /pmc/articles/PMC9370804/ /pubmed/35956297 http://dx.doi.org/10.3390/nu14153121 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Limin
Sato, Miori
Saito-Abe, Mayako
Miyaji, Yumiko
Sato, Chikako
Nishizato, Minaho
Kumasaka, Natsuhiko
Mezawa, Hidetoshi
Yamamoto-Hanada, Kiwako
Ohya, Yukihiro
Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study
title Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study
title_full Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study
title_fullStr Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study
title_full_unstemmed Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study
title_short Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children’s Study
title_sort smoking exposure is associated with serum vitamin d deficiency in children: evidence from the japan environment and children’s study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370804/
https://www.ncbi.nlm.nih.gov/pubmed/35956297
http://dx.doi.org/10.3390/nu14153121
work_keys_str_mv AT yanglimin smokingexposureisassociatedwithserumvitaminddeficiencyinchildrenevidencefromthejapanenvironmentandchildrensstudy
AT satomiori smokingexposureisassociatedwithserumvitaminddeficiencyinchildrenevidencefromthejapanenvironmentandchildrensstudy
AT saitoabemayako smokingexposureisassociatedwithserumvitaminddeficiencyinchildrenevidencefromthejapanenvironmentandchildrensstudy
AT miyajiyumiko smokingexposureisassociatedwithserumvitaminddeficiencyinchildrenevidencefromthejapanenvironmentandchildrensstudy
AT satochikako smokingexposureisassociatedwithserumvitaminddeficiencyinchildrenevidencefromthejapanenvironmentandchildrensstudy
AT nishizatominaho smokingexposureisassociatedwithserumvitaminddeficiencyinchildrenevidencefromthejapanenvironmentandchildrensstudy
AT kumasakanatsuhiko smokingexposureisassociatedwithserumvitaminddeficiencyinchildrenevidencefromthejapanenvironmentandchildrensstudy
AT mezawahidetoshi smokingexposureisassociatedwithserumvitaminddeficiencyinchildrenevidencefromthejapanenvironmentandchildrensstudy
AT yamamotohanadakiwako smokingexposureisassociatedwithserumvitaminddeficiencyinchildrenevidencefromthejapanenvironmentandchildrensstudy
AT ohyayukihiro smokingexposureisassociatedwithserumvitaminddeficiencyinchildrenevidencefromthejapanenvironmentandchildrensstudy